2013
Limiting Cardiac Ischemic Injury by Pharmacological Augmentation of Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Signal Transduction
Wang J, Tong C, Yan X, Yeung E, Gandavadi S, Hare AA, Du X, Chen Y, Xiong H, Ma C, Leng L, Young LH, Jorgensen WL, Li J, Bucala R. Limiting Cardiac Ischemic Injury by Pharmacological Augmentation of Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Signal Transduction. Circulation 2013, 128: 225-236. PMID: 23753877, PMCID: PMC3781594, DOI: 10.1161/circulationaha.112.000862.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsAntigens, Differentiation, B-LymphocyteCardiotonic AgentsCells, CulturedGlucoseHistocompatibility Antigens Class IIIntramolecular OxidoreductasesIsoxazolesMacrophage Migration-Inhibitory FactorsMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial InfarctionMyocardial IschemiaMyocytes, CardiacRecombinant ProteinsSignal TransductionConceptsMacrophage migration inhibitory factorCardiac ischemic injuryIschemic injuryProtective effectPostischemic left ventricular functionGlucose uptakeLeft coronary artery occlusionLeft ventricular functionCoronary artery occlusionIschemic tissue injuryMigration inhibitory factorMyocardial glucose uptakeAMPK activationTreatment of cardiomyocytesArtery occlusionMIF receptorVentricular functionIschemic myocardiumCellular glucose uptakeTissue injuryIschemia modelPharmacological augmentationFlow ischemiaSuch agonistsInhibitory factor
2002
Cardiac outcomes after myocardial infarction in elderly patients with diabetes mellitus.
Chyun D, Vaccarino V, Murillo J, Young LH, Krumholz HM. Cardiac outcomes after myocardial infarction in elderly patients with diabetes mellitus. American Journal Of Critical Care 2002, 11: 504-19. PMID: 12425401, DOI: 10.4037/ajcc2002.11.6.504.Peer-Reviewed Original ResearchConceptsRecurrent myocardial infarctionInsulin-treated diabetes mellitusDiabetes mellitusMyocardial infarctionElderly patientsHeart failureVentricular functionComorbid conditionsClinical findingsIndex myocardial infarctionPoor ventricular functionInsulin-treated diabetesAcute myocardial infarctionCardiac outcomesPoor outcomeMedical recordsMellitusInfarctionMedicare beneficiariesPatientsGreater riskInsulinMortalityRiskOutcomes
2001
Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
Russell R, Chyun D, Song S, Sherwin R, Tamborlane W, Lee F, Pfeifer M, Rife F, Wackers F, Young L. Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients. AJP Endocrinology And Metabolism 2001, 281: e1029-e1036. PMID: 11595660, DOI: 10.1152/ajpendo.2001.281.5.e1029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiac OutputCatecholaminesChemical PrecipitationDiabetes Mellitus, Type 1DiastoleEpinephrineFatty Acids, NonesterifiedFemaleGlucagonGlucose Clamp TechniqueHeartHeart RateHumansHydrocortisoneHypoglycemiaInsulinLactic AcidMaleNorepinephrinePolyethylene GlycolsStroke VolumeSystoleVentricular Function, LeftConceptsType 1 diabetic patientsInsulin-induced hypoglycemiaNondiabetic groupType 1 diabetesDiabetic subjectsEuglycemic hyperinsulinemiaDiabetic patientsNondiabetic subjectsCardiac responseLeft ventricular systolicHealthy nondiabetic subjectsEquilibrium radionuclide angiographyDiabetic groupDiastolic functionVentricular systolicCardiovascular consequencesVentricular functionBlunted increaseCardiac outputGlucagon concentrationsPlasma catecholaminesRadionuclide angiographyInsulin infusionEuglycemic conditionsHypoglycemia
1990
Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty
Young L, Jaffe C, Revkin J, McNulty P, Cleman M. Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty. The American Journal Of Cardiology 1990, 65: 986-990. PMID: 2327360, DOI: 10.1016/0002-9149(90)91001-m.Peer-Reviewed Original ResearchConceptsGreat cardiac veinDistal perfusionLactate releaseEjection fractionVentricular functionCardiac veinBalloon inflationLeft ventricular ejection fractionDistal coronary perfusionMyocardial lactate metabolismVentricular ejection fractionMyocardial lactate releaseRegional contractile functionNet lactate extractionNet lactate releaseCoronary angioplastyLeft anteriorCoronary perfusionLactate extractionContractile functionPerfusionAngioplastyLactate concentrationLactate metabolismOxygenated perfluorocarbon