2009
Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
KALMAR JH, WANG F, SPENCER L, EDMISTON E, LACADIE CM, MARTIN A, CONSTABLE RT, DUNCAN JS, STAIB LH, PAPADEMETRIS X, BLUMBERG HP. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. Journal Of The International Neuropsychological Society 2009, 15: 476-481. PMID: 19402934, PMCID: PMC2852397, DOI: 10.1017/s1355617709090584.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsVentral prefrontal cortexBipolar disorderYoung adultsBrain volume changesRostral anterior cingulate cortexPrevious cross-sectional studiesCross-sectional studyAdolescence/young adulthoodHigh-resolution magnetic resonanceAnterior cingulate cortexPreliminary evidenceVolume abnormalitiesHealthy comparison participantsPrefrontal abnormalitiesGreater volume lossCingulate cortexRegional volumesPrefrontal cortexModest sample sizeYoung adulthoodAdultsRostral PFCComparison participantsAbnormalities
2004
Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
Vythilingam M, Vermetten E, Anderson GM, Luckenbaugh D, Anderson ER, Snow J, Staib LH, Charney DS, Bremner JD. Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment. Biological Psychiatry 2004, 56: 101-112. PMID: 15231442, DOI: 10.1016/j.biopsych.2004.04.002.Peer-Reviewed Original ResearchConceptsMajor depressive disorderUrinary free cortisolHippocampal volumeHealthy subjectsMemory deficitsDepressed patientsDepressive disorderCortisol statusSelective serotonin reuptake inhibitor (SSRI) treatmentSerotonin reuptake inhibitor treatmentWechsler Memory Scale-RevisedNormal hippocampal volumesReuptake inhibitor treatmentWhole hippocampal volumeWhole brain volumeDeclarative memory deficitsEffect of treatmentMemory functionDeclarative memory functionUFC excretionAntidepressant treatmentFree cortisolHippocampal dysfunctionBaseline plasmaSuccessful treatment