2015
Anterior Cortical Development During Adolescence in Bipolar Disorder
Najt P, Wang F, Spencer L, Johnston JA, Lippard E, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder. Biological Psychiatry 2015, 79: 303-310. PMID: 26033826, PMCID: PMC4595154, DOI: 10.1016/j.biopsych.2015.03.026.Peer-Reviewed Original ResearchConceptsWhite matter expansionBipolar disorderWhite matterAnterior cortexHealthy adolescentsHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansWhite matter increasesResonance imaging scansGray matter decreasesDorsolateral prefrontal cortexMatter expansionHealthy groupImaging scansCortical volumeFrontal cortexNeurodevelopmental abnormalitiesCortical developmentAnterior paralimbicNeurodevelopmental modelLongitudinal neuroimagingPrefrontal cortexCortexLongitudinal studyAdolescentsThe clinical impact of gynecologic MRI.
Ratner ES, Staib LH, Cross SN, Raji R, Schwartz PE, McCarthy SM. The clinical impact of gynecologic MRI. American Journal Of Roentgenology 2015, 204: 674-80. PMID: 25714302, DOI: 10.2214/ajr.14.12567.Peer-Reviewed Original ResearchConceptsPelvic MRIFirst modalityClinical managementClinical impactGynecologic massesIndeterminate pelvic massesGroup of patientsResults of MRIRadiologic recordsRadiologic findingsPelvic massClinical recordsUnnecessary surgeryMedical recordsCT examinationsFurther endpointsExact diagnosisPatientsSurgeryIndeterminate massesPatient treatmentMRIDiagnosisModalitiesResultant anxietyUtility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions
Macer ML, Mathur M, Spektor M, Gysler S, Staib L, Kodaman P, McCarthy S. Utility of Magnetic Resonance Imaging in the Evaluation of Intraoperatively Confirmed Pelvic Adhesions. Journal Of Computer Assisted Tomography 2015, 39: 896-900. PMID: 26466105, DOI: 10.1097/rct.0000000000000302.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingPelvic adhesionsPositive predictive valuePredictive valueResonance imagingSpecificity of MRIGynecologic abdominal surgeryInstitutional review board-approved retrospective analysisNegative predictive valueAnterior culPosterior culAbdominal surgeryOperative reportsInclusion criteriaRetrospective analysisStudy populationBlinded specialistsMRI sensitivityPatientsImaging
2014
Using SUV as a Guide to 18F-FDG Dose Reduction
Cheng DW, Ersahin D, Staib LH, Della Latta D, Giorgetti A, d’Errico F. Using SUV as a Guide to 18F-FDG Dose Reduction. Journal Of Nuclear Medicine 2014, 55: 1998-2002. PMID: 25453048, DOI: 10.2967/jnumed.114.140129.Peer-Reviewed Original Research
2012
Anatomical Brain Images Alone Can Accurately Diagnose Chronic Neuropsychiatric Illnesses
Bansal R, Staib LH, Laine AF, Hao X, Xu D, Liu J, Weissman M, Peterson BS. Anatomical Brain Images Alone Can Accurately Diagnose Chronic Neuropsychiatric Illnesses. PLOS ONE 2012, 7: e50698. PMID: 23236384, PMCID: PMC3517530, DOI: 10.1371/journal.pone.0050698.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlgorithmsAttention Deficit Disorder with HyperactivityBipolar DisorderBrainChildDepressive Disorder, MajorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsSchizophreniaSensitivity and SpecificityTourette SyndromeConceptsBrains of personsNeuropsychiatric illnessBrain regionsNeuropsychiatric disordersMRI scansMajor depressive disorderChronic neuropsychiatric disorderAttention-deficit/hyperactivity disorderSpecific neuropsychiatric disordersDifferent neuropsychiatric disordersLarge MRI datasetsAnatomical MRI scansDisease courseCerebral cortexLow familial riskDepressive disorderBiological subtypesTourette syndromeBipolar disorderAnatomical brain imagesClinical diagnosisFamilial riskIllnessDiagnostic accuracyDiagnostic algorithmEarly assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma
Silva CT, Naveed N, Bokhari S, Baker KE, Staib LH, Ibrahim SM, Muchantef K, Goodman TR. Early assessment of the efficacy of digital infrared thermal imaging in pediatric extremity trauma. Emergency Radiology 2012, 19: 203-209. PMID: 22362422, DOI: 10.1007/s10140-012-1027-2.Peer-Reviewed Original ResearchConceptsPediatric extremity traumaExtremity traumaSite of painPediatric emergency departmentSite of injuryPain sitesEmergency departmentLimb traumaContralateral limbExtremity radiographsFracture sitePatientsFurther evaluationRadiographsTraumaSame dayEarly assessmentWhole limbIntellectual disabilityLocal hyperthermiaYoung childrenDITIEfficacyLimbFracturesThe Utility of I-123 Pretherapy Scan in I-131 Radioiodine Therapy for Thyroid Cancer
Chen MK, Yasrebi M, Samii J, Staib LH, Doddamane I, Cheng DW. The Utility of I-123 Pretherapy Scan in I-131 Radioiodine Therapy for Thyroid Cancer. Thyroid 2012, 22: 304-309. PMID: 22300251, DOI: 10.1089/thy.2011.0203.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, PapillaryAdenoma, OxyphilicAdolescentAdultAgedAged, 80 and overCarcinomaCarcinoma, PapillaryFemaleHumansIodine RadioisotopesMaleMiddle AgedNeoplasm MetastasisRadionuclide ImagingRadiopharmaceuticalsRetrospective StudiesThyroid Cancer, PapillaryThyroid NeoplasmsThyroidectomyConceptsPretherapy scansThyroid remnantsLymph nodesDistant metastasisYale-New Haven HospitalLarge thyroid remnantsCervical lymph nodesTime of thyroidectomyAdditional clinical informationNew Haven HospitalNeck uptakeRadioiodine therapyWhole-body imagesEuthyroid statePathology reportsThyroid cancerTreatment protocolLocal lymphClinical informationThyroidectomy specimensPretherapyConfidence intervalsScansThyroidectomyMetastasis
2011
Lateral ventricle volume and psychotic features in adolescents and adults with bipolar disorder
Edmiston EE, Wang F, Kalmar JH, Womer FY, Chepenik LG, Pittman B, Gueorguieva R, Hur E, Spencer L, Staib LH, Constable RT, Fulbright RK, Papademetris X, Blumberg HP. Lateral ventricle volume and psychotic features in adolescents and adults with bipolar disorder. Psychiatry Research 2011, 194: 400-402. PMID: 22041535, PMCID: PMC3225709, DOI: 10.1016/j.pscychresns.2011.07.005.Peer-Reviewed Original ResearchDiffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity
Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity. Australian & New Zealand Journal Of Psychiatry 2011, 45: 153-162. PMID: 21128874, PMCID: PMC3123660, DOI: 10.3109/00048674.2010.534069.Peer-Reviewed Original Research
2010
Image-Guided Intraoperative Cortical Deformation Recovery Using Game Theory: Application to Neocortical Epilepsy Surgery
DeLorenzo C, Papademetris X, Staib LH, Vives KP, Spencer DD, Duncan JS. Image-Guided Intraoperative Cortical Deformation Recovery Using Game Theory: Application to Neocortical Epilepsy Surgery. IEEE Transactions On Medical Imaging 2010, 29: 322-338. PMID: 20129844, PMCID: PMC2824434, DOI: 10.1109/tmi.2009.2027993.Peer-Reviewed Original ResearchConceptsDeformation estimationSurface deformationBrain surface deformationSurface deformation estimationPreoperative brain imagesCortical surface deformationSurface trackingCamera calibration parametersDisplacement errorStereo vision systemBrain deformationDeformationCalibration parametersBiomechanical modelIntraoperative brainCalibration errorsPhysical processesVision systemVivo casesCamera calibrationStereo systemInitial conditionsImage acquisitionErrorEstimation
2009
Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder
KALMAR JH, WANG F, SPENCER L, EDMISTON E, LACADIE CM, MARTIN A, CONSTABLE RT, DUNCAN JS, STAIB LH, PAPADEMETRIS X, BLUMBERG HP. Preliminary evidence for progressive prefrontal abnormalities in adolescents and young adults with bipolar disorder. Journal Of The International Neuropsychological Society 2009, 15: 476-481. PMID: 19402934, PMCID: PMC2852397, DOI: 10.1017/s1355617709090584.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsVentral prefrontal cortexBipolar disorderYoung adultsBrain volume changesRostral anterior cingulate cortexPrevious cross-sectional studiesCross-sectional studyAdolescence/young adulthoodHigh-resolution magnetic resonanceAnterior cingulate cortexPreliminary evidenceVolume abnormalitiesHealthy comparison participantsPrefrontal abnormalitiesGreater volume lossCingulate cortexRegional volumesPrefrontal cortexModest sample sizeYoung adulthoodAdultsRostral PFCComparison participantsAbnormalities
2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes
2004
Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder
Plessen KJ, Wentzel-Larsen T, Hugdahl K, Feineigle P, Klein J, Staib LH, Leckman JF, Bansal R, Peterson BS. Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder. American Journal Of Psychiatry 2004, 161: 2028-2037. PMID: 15514403, DOI: 10.1176/appi.ajp.161.11.2028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAttention Deficit Disorder with HyperactivityCase-Control StudiesCerebral CortexComorbidityCorpus CallosumCross-Sectional StudiesFunctional LateralityHumansMagnetic Resonance ImagingMaleNeuronal PlasticityObsessive-Compulsive DisorderPrefrontal CortexSeverity of Illness IndexTourette SyndromeConceptsCorpus callosum sizeCallosum sizeTourette's disorderCorpus callosumCerebral hemispheresComparison subjectsCross-sectional case-control studyMidsagittal corpus callosum areaCorpus callosum areaCase-control studyEffects of medicationAge 30 yearsCortical inhibitory interneuronsHigh-resolution magnetic resonanceHealthy comparison subjectsMajor commissureComorbid illnessesTic symptomsOrbitofrontal cortical volumeCortical volumeInhibitory interneuronsInterhemispheric connectivityInhibitory inputsTic severityPrior evidence
2003
Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome
Peterson BS, Thomas P, Kane MJ, Scahill L, Zhang H, Bronen R, King RA, Leckman JF, Staib L. Basal Ganglia Volumes in Patients With Gilles de la Tourette Syndrome. JAMA Psychiatry 2003, 60: 415-424. PMID: 12695320, DOI: 10.1001/archpsyc.60.4.415.Peer-Reviewed Original ResearchConceptsBasal ganglia volumesBasal gangliaCaudate nucleus volumeTourette syndromeGanglia volumesObsessive-compulsive disorderLenticular nucleus volumesTic symptomsNucleus volumeGilles dePathophysiology of TSPrior neuroleptic exposureHealthy control subjectsSeverity of ticsComorbid obsessive-compulsive disorderGreat clinical relevanceAttention-deficit/hyperactivity disorder (ADHD) symptomsHyperactivity disorder symptomsRepeated-measures analysisNeuroleptic exposureControl subjectsFunctional disturbancesTrait abnormalityClinical relevanceGanglia
2001
Regional Brain and Ventricular Volumes in Tourette Syndrome
Peterson BS, Staib L, Scahill L, Zhang H, Anderson C, Leckman JF, Cohen DJ, Gore JC, Albert J, Webster R. Regional Brain and Ventricular Volumes in Tourette Syndrome. JAMA Psychiatry 2001, 58: 427-440. PMID: 11343521, DOI: 10.1001/archpsyc.58.5.427.Peer-Reviewed Original ResearchConceptsParieto-occipital regionsTourette syndromeTic symptomsCerebral volumeVentricular volumePathophysiology of TST subjectsWhite matter portionsThalamo-cortical circuitrySignificant inverse associationRegional cerebral volumesHigh-resolution anatomical magnetic resonance imagesStandard anatomical landmarksSex differencesAge-related findingsDorsal prefrontal regionsRegional brainCortico-striatoHealthy childrenHealthy controlsInverse associationHealthy subjectsOccipital volumeTS groupCortical regionsAutomated measurement of latent morphological features in the human corpus callosum
Peterson B, Feineigle P, Staib L, Gore J. Automated measurement of latent morphological features in the human corpus callosum. Human Brain Mapping 2001, 12: 232-245. PMID: 11241874, PMCID: PMC6871880, DOI: 10.1002/1097-0193(200104)12:4<232::aid-hbm1018>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsCorpus callosumSubject characteristicsYears of ageHuman corpus callosumPatient groupCallosum sizeHealthy subjectsMRI scansVentricular volumeCallosumMidsagittal planeFactor scoresNeural correlatesConstruct validityFactor-based analysisConventional measuresFuture studiesMorphological featuresAgePredictive validitySubjectsScoresNormal developmentVarimax rotationFactorsGender differences in cognitive and neural correlates of remembrance of emotional words.
Bremner J, Soufer R, McCarthy G, Delaney R, Staib L, Duncan J, Charney D. Gender differences in cognitive and neural correlates of remembrance of emotional words. Psychopharmacology Bulletin 2001, 35: 55-78. PMID: 12397879.Peer-Reviewed Original ResearchConceptsEmotional wordsEmotional contentNeural correlatesWord pairsSuperior verbal memorySpecific cognitive functionsBilateral posterior hippocampusSuperior spatial memoryMedial prefrontal cortexGender differencesProcessing of informationNeutral wordsCognitive appraisalVerbal memoryPossible gender differencesHuman cognitionMemory performanceSet of listsGreater activationPosterior hippocampusPrefrontal cortexCognitive functionEmotional dimensionsSpatial memoryEmotional impact
2000
SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder
Bremner J, Innis R, White T, Fujita M, Silbersweig D, Goddard A, Staib L, Stern E, Cappiello A, Woods S, Baldwin R, Charney D. SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biological Psychiatry 2000, 47: 96-106. PMID: 10664825, DOI: 10.1016/s0006-3223(99)00188-2.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingBenzodiazepine receptor functionPanic disorder patientsBenzodiazepine receptorsPanic disorderReceptor bindingDisorder patientsPanic attacksReceptor functionPrefrontal cortexSingle photon emissionStatistical parametric mappingGABAergic transmissionHealthy controlsFrontal cortexLeft hippocampusAnimal modelsComparison subjectsPatientsChronic stressPanic anxietyTomography imagingParametric mappingCortexSpecific decrease
1999
Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects
Bremner J, Horti A, Staib L, Zea‐Ponce Y, Soufer R, Charney D, Baldwin R. Kinetic modeling of benzodiazepine receptor binding with PET and high specific activity [11C]Iomazenil in healthy human subjects. Synapse 1999, 35: 68-77. PMID: 10579810, DOI: 10.1002/(sici)1098-2396(200001)35:1<68::aid-syn9>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsBenzodiazepine receptor bindingHealthy human subjectsReceptor bindingBenzodiazepine receptorsHuman subjectsBenzodiazepine receptor antagonistCompartment modelReceptor antagonistMultiple time pointsBolus injectionArterial samplesTime-activity curvesSPECT radioligandBrain tissueBrain tissue compartmentsPET imagingTime pointsPrior reportsRadioligandParent compoundTissue compartmentsRadioligand concentrationHigh specific activityWiley-LissReceptors