2017
A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells
Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells. Biomaterials 2017, 154: 158-168. PMID: 29128844, DOI: 10.1016/j.biomaterials.2017.10.052.Peer-Reviewed Original ResearchConceptsRetinal degenerationNeurosensory retinaRetinal cellsHost retinal pigment epitheliumStem cellsOuter nuclear layerRetinal pigment epitheliumRetinal cell typesElaborate arborsQuantitative RT-PCRLeading causeImmune responseNuclear layerMouse modelPigment epitheliumSubretinal spaceForebrain cellsMinimal immune responseTherapeutic agentsRetinal laminationRT-PCRDegenerationRetinaRetinal organoidsConfocal immunocytochemistry
2008
A Novel Rabbit Model for Studying RPE Transplantation
Cong L, Sun D, Zhang Z, Jiao W, Rizzolo LJ, Peng S. A Novel Rabbit Model for Studying RPE Transplantation. Investigative Ophthalmology & Visual Science 2008, 49: 4115-4125. PMID: 18502985, PMCID: PMC2568003, DOI: 10.1167/iovs.08-1976.Peer-Reviewed Original ResearchConceptsOptical coherence tomographySubretinal spaceIntact blood-retinal barrierRetinal pigment epithelium (RPE) transplantationRabbit RPEBlood-retinal barrierConfocal scanning laserNovel rabbit modelZonula occludens-1CFDA-SEFunctional RPE monolayerTransepithelial electrical resistanceTransplanted RPEFundus photographyConjunctival flapRPE transplantationTransplantation protocolsLabeled cellsRabbit modelCoherence tomographyOccludens-1RPE cellsRPE monolayerPrimary cultures