2023
Chapter 1 Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration
Nasonkin I, Rizzolo L. Chapter 1 Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration. 2023, 1-41. DOI: 10.1016/b978-0-323-99987-8.00005-9.Peer-Reviewed Original ResearchStem cellsDifferent ocular tissuesActual clinical impactClinical translationEndogenous stem cellsCell transplantationVision lossEfficacious therapyClinical impactAnimal modelsOcular tissuesHuman patientsImpaired visionOcular repairPatientsClinicBench discoveriesTissue stem cellsLimited proliferationOrganoid culturesCellsInitial excitementTransplantationTherapy
2022
Retinal Cell Transplantation, Biomaterials, and In Vitro Models for Developing Next-generation Therapies of Age-related Macular Degeneration
Rizzolo LJ, Nasonkin IO, Adelman RA. Retinal Cell Transplantation, Biomaterials, and In Vitro Models for Developing Next-generation Therapies of Age-related Macular Degeneration. Stem Cells Translational Medicine 2022, 11: 269-281. PMID: 35356975, PMCID: PMC8968686, DOI: 10.1093/stcltm/szac001.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationMacular degenerationPathology of AMDOuter blood-retinal barrierBlood-retinal barrierRetinal pigment epithelium cellsRetinal degenerative conditionsRisky surgical procedureCell replacement mechanismLoss of photoreceptorsRetinal cell transplantationPigment epithelium cellsCell therapy approachesRPE patchesNext-generation therapiesTransplant proceduresCell transplantationRPE transplantsClinical trialsSurgical proceduresApical processesBasal sideDegenerative conditionsRPE apical processesSevere impairment