2007
Effect of Age and Comedication on Levetiracetam Pharmacokinetics and Tolerability
Hirsch LJ, Arif H, Buchsbaum R, Weintraub D, Lee J, Chang JT, Resor SR, Bazil CW. Effect of Age and Comedication on Levetiracetam Pharmacokinetics and Tolerability. Epilepsia 2007, 48: 1351-1359. PMID: 17573925, DOI: 10.1111/j.1528-1167.2007.01043.x.Peer-Reviewed Original ResearchConceptsTolerability of levetiracetamLEV clearanceOlder adultsYoung adultsAdverse effectsEnzyme-inducing antiepileptic drugsOlder groupSame serum levelsCommon adverse effectsSubgroup of patientsGroup of patientsSpecific adverse effectsBehavioral side effectsOne-year retentionLevetiracetam pharmacokineticsEffect of ageOlder patientsYounger patientsApparent clearanceSerum levelsAntiepileptic drugsLEV useAdult outpatientsLow doseLevetiracetam
2005
Effect of Antiepileptic Drug Comedication on Lamotrigine Clearance
Weintraub D, Buchsbaum R, Resor SR, Hirsch LJ. Effect of Antiepileptic Drug Comedication on Lamotrigine Clearance. JAMA Neurology 2005, 62: 1432-1436. PMID: 16157751, DOI: 10.1001/archneur.62.9.1432.Peer-Reviewed Original ResearchConceptsLamotrigine clearanceLamotrigine serum concentrationsNewer AEDsSerum concentrationsColumbia Comprehensive Epilepsy CenterComprehensive Epilepsy CenterLamotrigine monotherapyAdjunctive therapyMedical chartsEpilepsy centersComedicationMonotherapyBody weightPhenytoinValproatePatientsML/hAEDsClearanceSignificant predictorsCarbamazepineOxcarbazepinePredictorsLamotrigineTherapy