2021
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra NK, Engel J, Liebeskind DS, Sharma VK, Hirsch LJ, Kasner SE, French JA, Devinsky O, Friedman A, Dawson J, Quinn TJ, Selim M, de Havenon A, Yasuda CL, Cendes F, Benninger F, Zaveri HP, Burneo JG, Srivastava P, Singh M, Bhatia R, Vishnu VY, Bentes C, Ferro J, Weiss S, Sivaraju A, Kim JA, Galovic M, Gilmore EJ, Pitkänen A, Davis K, Sansing LH, Sheth KN, Paz JT, Singh A, Sheth S, Worrall BB, Grotta JC, Casillas-Espinos PM, Chen Z, Nicolo JP, Yan B, Kwan P, Consortium F. International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke. Epilepsy & Behavior 2021, 127: 108502. PMID: 34968775, DOI: 10.1016/j.yebeh.2021.108502.Peer-Reviewed Original ResearchPharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus
Bravo P, Vaddiparti A, Hirsch LJ. Pharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus. Drugs 2021, 81: 749-770. PMID: 33830480, DOI: 10.1007/s40265-021-01502-4.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusAntiseizure medicationsNonconvulsive seizuresStatus epilepticusIll patientsRefractory nonconvulsive status epilepticusFurther neurological injuryMultiple antiseizure medicationsAdverse neurological outcomesContinuous electroencephalogram monitoringLong-term outcomesHemodynamic labilityRecent neurosurgerySeizure burdenNeurological outcomePharmacological managementBrain infectionGlobal hypoxiaNeurological injuryEarly recognitionMost seizuresUnderlying conditionClinical trialsElectroencephalogram monitoringHepatic function
2017
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks‐Kayal A, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia 2017, 59: 37-66. PMID: 29247482, PMCID: PMC5993212, DOI: 10.1111/epi.13965.Peer-Reviewed Original ResearchConceptsAcute brain insultsAnimal modelsPrevention therapyBrain insultsBrain injuryInjury etiologyHuman epilepsyClinical testingCentral nervous system infectionFluid percussion injury modelTemporal lobe epilepsy patientsPost-status epilepticus modelDisease modification strategiesNervous system infectionMolecular targetsBetter patient selectionInflammatory cellular infiltrateLoss of neuronsWeeks of injuryBlood-brain barrierTraumatic brain injuryPreclinical animal modelsGap junction couplingCommon histopathologicEpilepsy prevention
2015
The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts
Löscher W, Hirsch LJ, Schmidt D. The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts. Epilepsy & Behavior 2015, 52: 78-92. PMID: 26409135, DOI: 10.1016/j.yebeh.2015.08.037.Peer-Reviewed Original ResearchConceptsBrain injuryLatent periodBrain insultsAnimal modelsMajor unmet clinical needPre-epileptic stateProcess of epileptogenesisUnderstanding of epileptogenesisTraumatic brain injuryUnmet clinical needAntiepileptogenic agentsAntiepileptogenic treatmentsSymptomatic epilepsyHuman epilepsyTrial designFunctional alterationsEpileptogenesisEpilepsySubclinical epilepsyClinical needInjuryPatientsRecent dataInsultPeriodMarijuana Use in Epilepsy: The Myth and the Reality
Detyniecki K, Hirsch L. Marijuana Use in Epilepsy: The Myth and the Reality. Current Neurology And Neuroscience Reports 2015, 15: 65. PMID: 26299273, DOI: 10.1007/s11910-015-0586-5.Peer-Reviewed Original ResearchConceptsUse of marijuanaPediatric casesSafety dataAnticonvulsant propertiesHuman evidenceHuman studiesEpilepsyCannabis extractsAvailable evidenceMarijuana extractDifferent cannabinoidsMarijuana useCannabidiolMarijuanaTetrahydrocannabinolMedicinal plantsPatientsVariety of conditionsCliniciansPhysicians
2014
A new encephalitis with GABAA receptor antibodies
Hirsch LJ. A new encephalitis with GABAA receptor antibodies. The Lancet Neurology 2014, 13: 239-240. PMID: 24462239, DOI: 10.1016/s1474-4422(14)70013-4.Peer-Reviewed Original Research
2010
Is sudden unexpected death in epilepsy due to postictal brain shutdown?
Hirsch LJ. Is sudden unexpected death in epilepsy due to postictal brain shutdown? Annals Of Neurology 2010, 68: 773-775. PMID: 21194146, DOI: 10.1002/ana.22242.Peer-Reviewed Original Research
2002
The current state of treatment of status epilepticus
Hirsch LJ, Claassen J. The current state of treatment of status epilepticus. Current Neurology And Neuroscience Reports 2002, 2: 345-356. PMID: 12044254, DOI: 10.1007/s11910-002-0010-9.Peer-Reviewed Original ResearchConceptsStatus epilepticusRefractory status epilepticusConvulsive status epilepticusNonconvulsive status epilepticusCertain EEG patternsAmbulatory patientsConfusional stateIll patientsClinical trialsEarly treatmentAnesthetic agentsEpilepticusClinical careEEG patternsPatientsTreatmentElectroencephalogram (EEG) recordingsMidazolamPropofolDiagnosis