2020
Assessment of the Validity of the 2HELPS2B Score for Inpatient Seizure Risk Prediction
Struck AF, Tabaeizadeh M, Schmitt SE, Ruiz AR, Swisher CB, Subramaniam T, Hernandez C, Kaleem S, Haider HA, Cissé AF, Dhakar MB, Hirsch LJ, Rosenthal ES, Zafar SF, Gaspard N, Westover MB. Assessment of the Validity of the 2HELPS2B Score for Inpatient Seizure Risk Prediction. JAMA Neurology 2020, 77: 500-507. PMID: 31930362, PMCID: PMC6990873, DOI: 10.1001/jamaneurol.2019.4656.Peer-Reviewed Original ResearchConceptsContinuous electroencephalogramValidation cohortMAIN OUTCOMEEEG monitoringRetrospective medical record reviewKaplan-Meier survival analysisPatients 18 yearsMedical record reviewRisk of seizuresHigh-risk groupFirst hourEpileptiform EEG patternCEEG useClinical seizuresPrimary outcomeHospitalized patientsRecord reviewRisk stratificationEpileptiform findingsCardiac arrestSeizure riskClinical indicationsInclusion criteriaIndependent cohortAdequate screen
2002
Levetiracetam May Be More Effective for Late-Onset Partial Epilepsy
Bazil CW, Rose A, Resor S, Yapicular B, Hirsch LJ. Levetiracetam May Be More Effective for Late-Onset Partial Epilepsy. JAMA Neurology 2002, 59: 1905-1908. PMID: 12470178, DOI: 10.1001/archneur.59.12.1905.Peer-Reviewed Original ResearchConceptsLevetiracetam therapySeizure typesRetrospective medical record reviewFrontal lobe onsetSame seizure typesTemporal lobe onsetLarge prospective trialsMedical record reviewSubset of patientsPopulation of patientsLocalization-related epilepsyNew antiepileptic drugsProspective trialRefractory epilepsyRecord reviewAntiepileptic drugsPartial epilepsySignificant worseningDrug choiceClinical experiencePatientsEpileptic seizuresEpilepsyCertain drugsCertain subpopulations