Role of ascorbic acid in cardiac allograft vasculopathy
Chang A, Martin K, Colvin M, Bellumkonda L. Role of ascorbic acid in cardiac allograft vasculopathy. Clinical Transplantation 2023, 37: e15153. PMID: 37792313, DOI: 10.1111/ctr.15153.Peer-Reviewed Original ResearchConceptsCardiac allograft vasculopathySmooth muscle cell apoptosisAllograft vasculopathyDisease processMuscle cell apoptosisSignificant long-term morbidityCell apoptosisProgressive fibroproliferative diseasePost-transplant carePost-transplant managementLong-term morbiditySmall clinical trialsChallenging disease processVascular smooth muscle cell apoptosisHeart transplantationCAV progressionEndothelial dysfunctionRapamycin inhibitorsClinical trialsIntimal thickeningPrevents developmentInterferon γRodent modelsIntimal hyperplasiaMTOR inhibitorsDual organ transplantation: when heart alone is not enough
Nuqali A, Bellumkonda L. Dual organ transplantation: when heart alone is not enough. Current Opinion In Organ Transplantation 2023, 28: 370-375. PMID: 37582057, DOI: 10.1097/mot.0000000000001093.Peer-Reviewed Original ResearchConceptsDual-organ transplantationOrgan transplantationPatient selectionBetter long-term outcomesDual organ transplantsSingle organ transplantationTransplant center experienceLong-term outcomesAdvanced disease processLong-term managementPosttransplant outcomesCenter experienceImmunological advantageOrgan transplantsDisease processPartial toleranceSecond organPatientsTransplantationLack of standardizationOutcomesOrgansUrgent needTransplant