2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingDiastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracicKiosk 8Q-FA-03 Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma
Khattab M, Kwan J, Alkhatib D, Shen M, Desai S, Akintoye E, Huber S, Baldassarre L. Kiosk 8Q-FA-03 Gedatolisib Associated Acute Myocarditis in a Patient with Breast Adenocarcinoma. Journal Of Cardiovascular Magnetic Resonance 2024, 26: 100856. PMID: 39155091, DOI: 10.1016/j.jocmr.2024.100856.Peer-Reviewed Original ResearchMultimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions
Bullock-Palmer R, Rosario K, Douglas P, Hahn R, Lang R, Chareonthaitawee P, Srichai M, Ordovas K, Baldassarre L, Burroughs M, Henderson C, Woodard P, Pressoir K, Swaminathan M, Blankstein R, Daubert M. Multimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions. Circulation Cardiovascular Imaging 2024, 17: e016409. PMID: 38377238, DOI: 10.1161/circimaging.123.016409.Peer-Reviewed Original Research
2023
SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction
Avula V, Sharma G, Kosiborod M, Vaduganathan M, Neilan T, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang E, Ky B, Lenihan D, Nohria A, Dani S, Ganatra S. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction. JACC Heart Failure 2023, 12: 67-78. PMID: 37897456, DOI: 10.1016/j.jchf.2023.08.026.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionSGLT2 inhibitor useGuideline-directed medical therapyHeart failureInhibitor useSGLT2 inhibitorsMedical therapyCardiac dysfunctionAntineoplastic therapyAtrial fibrillation/flutterType 2 diabetes mellitusAcute HF exacerbationCox proportional HRsAcute kidney injuryRenal replacement therapyRetrospective cohort analysisIschemic heart diseaseRisk of cardiomyopathyAggregate patient dataTriNetX Research NetworkProportional HRsCause hospitalizationCause mortalityHF exacerbationKidney injuryAtrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation
Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, PMCID: PMC11378145, DOI: 10.1007/s10554-023-02968-x.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLA reservoir strainLeft atrial pressureLA volumeReservoir strainLA fibrosisLA strainStiffness indexLA late gadolinium enhancementAtrial stiffness indexMaximal LA volumeAtrial fibrillation cohortLA minimum volumeAtrial tissue fibrosisMaximum LA volumeCardiac MR examsAtrial stiffnessAtrial strainAF ablationAtrial pressureAF cohortAtrial fibrillationAtrial fibrosisPatient subgroupsLGE volumeScientific document development standards for the society of cardiovascular computed tomography (SCCT): A statement from the SCCT Guidelines Committee
Baldassarre L, Koweek L, Andreini D, Branch K, Brennaman D, Budde R, De La O S, Fairbairn T, Hedgire S, Weir-McCall J, Woodard P, Wong D, Chen M, Committee S. Scientific document development standards for the society of cardiovascular computed tomography (SCCT): A statement from the SCCT Guidelines Committee. Journal Of Cardiovascular Computed Tomography 2023, 17: 459-464. PMID: 37429770, DOI: 10.1016/j.jcct.2023.06.006.Peer-Reviewed Original ResearchQuantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients
Kwan J, Arbune A, Henry M, Hu R, Wei W, Nguyen V, Lee S, Lopez-Mattei J, Guha A, Huber S, Bader A, Meadows J, Sinusas A, Mojibian H, Peters D, Lustberg M, Hull S, Baldassarre L. Quantitative cardiovascular magnetic resonance findings and clinical risk factors predict cardiovascular outcomes in breast cancer patients. PLOS ONE 2023, 18: e0286364. PMID: 37252927, PMCID: PMC10228774, DOI: 10.1371/journal.pone.0286364.Peer-Reviewed Original ResearchConceptsBreast cancer patientsSystolic heart failureCardiovascular outcomesCancer patientsHeart failureValvular diseaseStrain abnormalitiesLeft ventricular ejection fraction reductionCancer treatment-related cardiotoxicityCardiovascular magnetic resonance findingsVentricular ejection fraction reductionYale-New Haven HospitalEjection fraction reductionTreatment-related cardiotoxicityAdverse cardiovascular outcomesClinical risk factorsNormal LV functionGlobal longitudinal strainIschemic heart diseaseMagnetic resonance findingsRisk regression modelsNew Haven HospitalSubclinical cardiotoxicityDiastolic dysfunctionStatin useAdvances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care
Bienstock S, Lin F, Blankstein R, Leipsic J, Cardoso R, Ahmadi A, Gelijns A, Patel K, Baldassarre L, Hadley M, LaRocca G, Sanz J, Narula J, Chandrashekhar Y, Shaw L, Fuster V. Advances in Coronary Computed Tomographic Angiographic Imaging of Atherosclerosis for Risk Stratification and Preventive Care. JACC Cardiovascular Imaging 2023, 16: 1099-1115. PMID: 37178070, DOI: 10.1016/j.jcmg.2023.02.002.Peer-Reviewed Original ResearchConceptsCoronary Computed Tomography AngiographyCoronary artery diseaseAtherosclerotic plaquesArtery diseaseRisk stratificationPreventive carePlaque volumeHigh-risk plaque featuresNonobstructive coronary artery diseaseCoronary CTAMeasurements of atherosclerosisEffective risk stratificationHigh-risk patientsTotal plaque volumeComputed tomography angiographyPatient-specific factorsCoronary artery dimensionsIntravascular ultrasound measurementsHealth care systemCoronary dominanceCardiovascular preventionPatient subsetsPlaque featuresArtery sizeTomography angiographyImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strainMyocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement
Vidula M, Rajewska-Tabor J, Cao J, Kang Y, Craft J, Mei W, Chandrasekaran P, Clark D, Poenar A, Gorecka M, Malahfji M, Cowan E, Kwan J, Reinhardt S, Al-Tabatabaee S, Doeblin P, Villa A, Karagodin I, Alvi N, Christia P, Spetko N, Cassar M, Park C, Nambiar L, Turgut A, Azad M, Lambers M, Wong T, Salerno M, Kim J, Elliott M, Raman B, Neubauer S, Tsao C, LaRocca G, Patel A, Chiribiri A, Kelle S, Baldassarre L, Shah D, Hughes S, Tong M, Pyda M, Simonetti O, Plein S, Han Y. Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement. JACC Cardiovascular Imaging 2023, 16: 609-624. PMID: 36752429, PMCID: PMC9833283, DOI: 10.1016/j.jcmg.2022.10.021.Peer-Reviewed Original ResearchConceptsCardiac magnetic resonanceNatriuretic peptide elevationMyocardial injuryIschemic patternTroponin elevationCardiac involvementChest discomfortInjury patternsCOVID-19Cardiac biomarker elevationCOVID-19 infectionAcute myocarditisAcute ischemicBiomarker elevationCardiac symptomsClinical suspicionCoronary diseaseMulticenter cohortAbnormal electrocardiogramMulticenter studyRetrospective studyECG abnormalitiesUnivariate analysisPatientsMultivariate analysis
2022
Advances in Multimodality Imaging in Cardio-Oncology JACC State-of-the-Art Review
Baldassarre LA, Ganatra S, Lopez-Mattei J, Yang EH, Zaha VG, Wong TC, Ayoub C, DeCara JM, Dent S, Deswal A, Ghosh AK, Henry M, Khemka A, Leja M, Rudski L, Villarraga HR, Liu JE, Barac A, Scherrer-Crosbie M, Councils A. Advances in Multimodality Imaging in Cardio-Oncology JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2022, 80: 1560-1578. PMID: 36229093, DOI: 10.1016/j.jacc.2022.08.743.Peer-Reviewed Original ResearchConceptsCardio-oncology patientsAdverse cardiovascular effectsLong-term survivorsPopulation of patientsCardiovascular complicationsPregnant patientsCardiovascular effectsCardiac massAntineoplastic therapyJACC StateVascular toxicityPatientsMultimodality imagingCancerImagingNumerous advancesReviewComplicationsAtherosclerosisTherapyPopulationDiseaseSurvivorsDiagnosisCardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS)
Lopez-Mattei J, Yang EH, Baldassarre LA, Agha A, Blankstein R, Choi AD, Chen MY, Meyersohn N, Daly R, Slim A, Rochitte C, Blaha M, Whelton S, Dzaye O, Dent S, Milgrom S, Ky B, Iliescu C, Mamas MA, Ferencik M. Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS). Journal Of Cardiovascular Computed Tomography 2022, 17: 66-83. PMID: 36216699, DOI: 10.1016/j.jcct.2022.09.002.Peer-Reviewed Original ResearchConceptsCardio-OncologyCardiac CTCardio-oncology patientsExpert consensus statementCardiovascular Computed TomographyExpert consensus documentConsensus statementComputed tomographyCurrent evidenceConsensus documentMultimodality imagingPractice recommendationsRadiation oncologyCCT applicationMultidisciplinary collaborationOncologyTomographic imagingImagingPatientsLimited guidanceCardiacCliniciansCardiologyCTCareCoronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry
Nowatzke J, Guedeney P, Palaskas N, Lehmann L, Ederhy S, Zhu H, Cautela J, Francis S, Courand PY, Deswal A, Ewer SM, Aras M, Arangalage D, Ghafourian K, Fenioux C, Finke D, Peretto G, Zaha V, Zadok O, Tajiri K, Akhter N, Levenson J, Baldassarre L, Power J, Huang S, Collet JP, Moslehi J, Salem JE, contributors I, Aghel N, Alexandre J, Aonuma K, Asnani A, Behling J, Bilen M, Bottinor W, Cariou E, Chahine J, Chan W, Chauhan A, Cohen M, Crusz S, Fernando S, Florido R, Frigeri M, Fukushima S, Gaughan E, Geisler B, Gilstrap L, Grohe C, Guha A, Habib M, Haegler-Laube E, Haydon A, Hayek S, Hughes A, Imai R, Katsume Y, Kimura H, Lin L, Lenneman C, Leong D, Makker V, Martinez-Calle N, Moey M, Mohri M, Morimoto R, Moritoki Y, Narezkina A, Nicol M, Nooka A, Orimoloye O, Patel M, Perl M, Piriou N, Raikhelkar J, Raza Y, Rao A, Reddy S, Seki N, Stangl K, Stewart A, Stringer B, Tamarappoo B, Tamura Y, Thuny F, Tierney S, Tresorier R, Ullah W, Von Hunolstein J, Warner E, Weppler A. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry. European Journal Of Cancer 2022, 177: 197-205. PMID: 36030143, PMCID: PMC10165738, DOI: 10.1016/j.ejca.2022.07.018.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseImmune checkpoint blockersCoronary revascularizationArtery diseaseCAD groupInternational registryPrompt clinical diagnosisAcute coronary syndromeCoronary artery stenosisAdjustment of ageCause deathCoronary syndromeIndex hospitalisationSteroid administrationCheckpoint blockersCoronary angiographyArtery stenosisCoronary angiogramPoor outcomeSevere presentationRevascularizationPatientsCardiac pathologyClinical diagnosisMyocarditisShort-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination
Pareek M, Steele J, Asnes J, Baldassarre L, Casale L, Desai N, Elder R, Faherty E, Ferguson I, Fishman R, Ghazizadeh Z, Glick L, Hall E, Khera R, Kokkinidis D, Kwan J, O'Marr J, Schussheim A, Tuohy E, Wang Y, Spatz E, Jacoby D, Miller E. Short-Term Outcomes After Myopericarditis Related to COVID-19 Vaccination. JACC Cardiovascular Imaging 2022, 15: 2002-2005. PMID: 36357140, PMCID: PMC9094612, DOI: 10.1016/j.jcmg.2022.03.026.Peer-Reviewed Case Reports and Technical Notes
2021
Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience
Batra A, Patel B, Addison D, Baldassarre LA, Desai N, Weintraub N, Deswal A, Hussain Z, Brown SA, Ganatra S, Agarwala V, Parikh PM, Fradley M, Ghosh A, Guha A. Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience. Open Heart 2021, 8: e001849. PMID: 34952868, PMCID: PMC8710909, DOI: 10.1136/openhrt-2021-001849.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsAdverse Event Reporting SystemCombination therapyAntimicrotubular agentsVinca alkaloidsAdverse eventsDrug Administration Adverse Event Reporting SystemRoutine cardiovascular assessmentCardiovascular safety profilePolytomous logistic regressionEvent Reporting SystemAgent therapyCombination chemotherapyHeart failureRegistry experienceSafety profileCardiovascular assessmentHigh burdenInhibitor combinationsChemotherapeutic agentsTaxanesTherapyLogistic regressionMonotherapyReporting systemLeft atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers
Peters DC, Lamy J, Sinusas AJ, Baldassarre LA. Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers. European Heart Journal - Cardiovascular Imaging 2021, 23: 14-30. PMID: 34718484, PMCID: PMC8685602, DOI: 10.1093/ehjci/jeab221.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementAtrial fibrillationCardiovascular magnetic resonanceDiastolic dysfunctionEjection fractionAF recurrenceAtrial fibrosisNew-onset atrial fibrillationPost-operative atrial fibrillationLongitudinal LA strainExtent of fibrosisLong-axis cine imagesCine imagesAtrial imagingCardiovascular eventsLA volumeRisk stratificationAF subjectsPrognostic informationHypertrophic cardiomyopathyLA strainGadolinium enhancementSensitive markerAblation proceduresMagnetic resonanceAre cardiology fellows receiving enough basic level I cardiovascular computed tomography education during their general fellowship training? Insights from a needs assessment survey at an academic medical center
Hur DJ, Meadows JL, Baldassarre LA, Mojibian HR, Villines TC, Windish DM. Are cardiology fellows receiving enough basic level I cardiovascular computed tomography education during their general fellowship training? Insights from a needs assessment survey at an academic medical center. Journal Of Cardiovascular Computed Tomography 2021, 16: 186-188. PMID: 34600865, DOI: 10.1016/j.jcct.2021.09.005.Peer-Reviewed Original ResearchAdverse thrombo-embolic events with newer tyrosine kinase inhibitors: a call to action for better risk stratification and monitoring
Hussain Z, Baldassarre L, Dent S, Weintraub NL, Guha A. Adverse thrombo-embolic events with newer tyrosine kinase inhibitors: a call to action for better risk stratification and monitoring. European Journal Of Preventive Cardiology 2021, 29: 1309-1311. PMID: 34219160, DOI: 10.1093/eurjpc/zwab055.Peer-Reviewed Original ResearchFat-saturated dark-blood cardiac T2 mapping in a single breath-hold
Hu C, Huber S, Nguyen V, Baldassarre L, Mojibian H, Peters D. Fat-saturated dark-blood cardiac T2 mapping in a single breath-hold. Magnetic Resonance Imaging 2021, 81: 24-32. PMID: 34044065, DOI: 10.1016/j.mri.2021.05.004.Peer-Reviewed Original Research