Laura Chen, MD
Assistant Professor of Pediatrics (Pulmonology)Cards
About
Research
Publications
2025
Bronchopulmonary Dysplasia in the First Year: Insights Into Severity, Medication Use, and Healthcare Utilization
Brumer E, Shabanova V, Urbach H, Montgomery A, Grossman M, Chen L, Weiss P, Kandil S. Bronchopulmonary Dysplasia in the First Year: Insights Into Severity, Medication Use, and Healthcare Utilization. Pediatric Pulmonology 2025, 60: e71254. PMID: 40855960, DOI: 10.1002/ppul.71254.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia severityBronchopulmonary dysplasiaFollow-upNICU admissionSystemic steroidsGrade 3Dexamethasone administrationGrade 2Respiratory morbidityRespiratory outcomesHealthcare utilizationGrade 1Post-NICU dischargeChronic lung diseaseRetrospective cohort studyPrevalence of prescriptionsHospital visitsSignificant disease burdenLongitudinal Follow-upPremature infantsDexamethasone useInhaled CorticosteroidsMild diseaseLung diseaseCohort studyEnsuring Timely Pulmonary Follow-up after an Inpatient Asthma Hospitalization: A Quality Improvement Initiative
Chandrasekar L, Schaffer H, Godse S, Grossman M, Chen L, Brumer E. Ensuring Timely Pulmonary Follow-up after an Inpatient Asthma Hospitalization: A Quality Improvement Initiative. Pediatric Quality And Safety 2025, 10: e815. PMID: 40371048, PMCID: PMC12077554, DOI: 10.1097/pq9.0000000000000815.Peer-Reviewed Original ResearchQuality improvement initiativesFollow-up appointmentsImprovement initiativesAttendance ratesAsthma exacerbationsTimely outpatient follow-upAppointment attendance ratesAsthma care guidelinesDays of hospital dischargeFollow-upPulmonary follow-upInconsistent careAcute asthma exacerbationAsthma hospitalizationsCare guidelinesVisit attendanceOutpatient follow-upPediatric intensive care unitActivity remindersAsthma controlOutcome measuresMultidisciplinary teamHospital dischargePrevent future episodesPulmonary consultationSingle cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma
Thompson D, Wabara Y, Duran S, Reichenbach A, Chen L, Collado K, Yon C, Greally DMed J, Rastogi D. Single cell analysis identifies distinct CD4 + T cells associated with the pathobiology of pediatric obesity related asthma. Scientific Reports 2025, 15: 6844. PMID: 40000680, PMCID: PMC11861978, DOI: 10.1038/s41598-025-88423-4.Peer-Reviewed Original ResearchConceptsCD4+ T cellsT cellsSteroid resistanceTh1 inflammationObese asthmaTh1 responseCentral memory T cellsSingle-cell transcriptomicsObese asthma phenotypeEffector T cellsMemory T cellsObesity-related asthmaPediatric obesity-related asthmaT cell subtypesT helper 1Healthy-weight controlsPulmonary function deficitsCD4Th1Asthma phenotypesGlucocorticoid receptorFunctional deficitsInflammationAsthmaUpregulation
2024
Caregivers of children with asthma alarmed by climate change: a cross‐sectional study
Godse S, Shabanova V, Ragavan M, Mitchell M, Chen L, Flom J, Sheares B. Caregivers of children with asthma alarmed by climate change: a cross‐sectional study. Pediatric Pulmonology 2024, 59: 3677-3685. PMID: 39323113, DOI: 10.1002/ppul.27288.Peer-Reviewed Original ResearchCaregivers of childrenCross-sectional studyClimate change-related health risksHealth impacts of climate changeInforming public health policyPublic health policiesReports adverse impactsRespiratory health impactsCaregiver perspectivesCaregiver perceptionsChild's asthmaHealth policyChild healthChild's doctorHealth harmsHealth risksCaregiversWorsening asthma controlAsthma controlAir pollutionAdverse health effectsPulmonology clinicSurvey instrumentUS settingHealth effectsQuality Improvement Initiative Enhances Outpatient Pediatric Pulmonology Follow-up for Premature Infants with Bronchopulmonary Dysplasia
Brumer E, Godse S, Chandrasekar L, Kizilirmak T, Blythe E, Gozzo Y, Peterec S, Kandil S, Grossman M, Chen L, Weiss P, Sheares B. Quality Improvement Initiative Enhances Outpatient Pediatric Pulmonology Follow-up for Premature Infants with Bronchopulmonary Dysplasia. Pediatric Quality And Safety 2024, 9: e736. PMID: 38854502, PMCID: PMC11161285, DOI: 10.1097/pq9.0000000000000736.Peer-Reviewed Original ResearchSevere bronchopulmonary dysplasiaBronchopulmonary dysplasiaPremature infantsFollow-upClassification of bronchopulmonary dysplasiaDiagnosis of bronchopulmonary dysplasiaYale-New Haven Children's HospitalBronchopulmonary dysplasia severityFollow-up of childrenPulmonary follow-upStandard treatment optionPercentage of patientsRespiratory-related morbidityPremature babiesInternational Classification of DiseasesAccuracy of diagnosisTreatment optionsCorrect diagnosisChildren's HospitalQuality improvement initiativesQuality improvement projectClassification of diseasesMedical recordsPercentage of appointmentsElectronic medical recordsWhen lungs and weights tell different stories
Godse S, Brumer E, Kizilirmak T, Canapari C, Silva C, Morotti R, Jiang Y, Jeffries L, Chen L, Panacherry S. When lungs and weights tell different stories. Pediatric Pulmonology 2024, 59: 1047-1059. PMID: 38353400, DOI: 10.1002/ppul.26832.Peer-Reviewed Original Research
2022
Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children
Chen L, Agalliu I, Roth A, Rastogi D. Association of fractional exhaled nitric oxide with asthma morbidity in urban minority children. Journal Of Asthma 2022, 60: 553-564. PMID: 35499408, PMCID: PMC10170416, DOI: 10.1080/02770903.2022.2073549.Peer-Reviewed Original ResearchConceptsPulmonary function testsFractional exhaled nitric oxideHigher FeNO levelsFeNO levelsExhaled Nitric OxideAssociated with higher BMI z-scoreHispanic childrenHigher BMI z-scoreClinical characteristicsFeNO measurementsAirway obstructionUrban minority childrenBMI z-scoreAsthma-related morbidityMixed effects linear regression modelsMinority childrenHighest proportion of childrenEffects linear regression modelsAssociation of changesLow FeNO levelsAllergic airway inflammationAssociation of baselineRetrospective chart reviewBaseline FeNO levelsProportion of children
2020
Pulmonary disease burden in Hispanic and non‐Hispanic children with sickle cell disease
Chen L, Gong J, Matta E, Morrone K, Manwani D, Rastogi D, De A. Pulmonary disease burden in Hispanic and non‐Hispanic children with sickle cell disease. Pediatric Pulmonology 2020, 55: 2064-2073. PMID: 32484996, DOI: 10.1002/ppul.24883.Peer-Reviewed Original ResearchConceptsAcute chest syndromeSickle cell diseasePulmonary disease burdenVaso-occlusive crisisHispanic patientsDisease burdenNon-Hispanic childrenCell diseaseVital capacitySickle cell disease patientsSickle cell disease related complicationsLeukotriene receptor antagonistsNon-HispanicRetrospective chart reviewPulmonary function profileHispanic childrenForced Vital CapacityAssociation of asthmaPulmonary complicationsBurden of sickle cell diseaseChest syndromePulmonary evaluationReceptor antagonistExchange transfusionInhaled CorticosteroidsContribution of systemic and airway immune responses to pediatric obesity-related asthma
Chen L, Collado K, Rastogi D. Contribution of systemic and airway immune responses to pediatric obesity-related asthma. Paediatric Respiratory Reviews 2020, 37: 3-9. PMID: 32253127, PMCID: PMC8477371, DOI: 10.1016/j.prrv.2020.02.005.Peer-Reviewed Original ResearchConceptsObesity-related asthmaImmune responseDifferentiation to Th1 cellsTh cell responsesAirway immune responsesNormal-weight childrenPediatric obesity-related asthmaTh1 cellsObese childrenCytokine productionUpregulation of genesChildhood obesityNon-allergicCdc42 pathwayCell physiologyCell responsesEpigenetic mechanismsDisease burdenAsthmaAirwayObesityCdc42DiseasePathwayPreliminary evidence
Clinical Care
Overview
Laura Chen, MD, is a pediatric pulmonologist who diagnoses and treats a range of respiratory conditions in children.
Dr. Chen focuses primarily on asthma, pulmonary manifestations of sickle cell disease, and aerodigestive disorders, which involve the complex interaction between the respiratory and digestive systems, often affecting breathing, swallowing, and digestion.
Dr. Chen is an assistant professor of pediatrics at Yale School of Medicine and received her medical training from Stony Brook University School of Medicine. She completed her residency in pediatrics and fellowship in pediatric pulmonology at the Children’s Hospital at Montefiore.
Clinical Specialties
Pediatric Pulmonology
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