2023
Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids
Zheng J, Sun B, Berardi D, Lu L, Yan H, Zheng S, Aladelokun O, Xie Y, Cai Y, Pollitt K, Khan S, Johnson C. Perfluorooctanesulfonic Acid and Perfluorooctanoic Acid Promote Migration of Three-Dimensional Colorectal Cancer Spheroids. Environmental Science And Technology 2023, 57: 21016-21028. PMID: 38064429, DOI: 10.1021/acs.est.3c04844.Peer-Reviewed Original ResearchConceptsColorectal cancerFatty acid β-oxidationCell linesSW48 cell linesSynthesis of proteinsProgression of CRCMigration phenotypeCRC cell linesEpithelial-mesenchymal transitionThree-dimensional spheroidsMetabolic pathwaysN-cadherinΒ-oxidationMechanism of actionNovel insightsE-cadherinBiological techniquesPromotes MigrationColorectal cancer spheroidsMigration assaysMetabolic profilingKRAS G12APerfluorooctanoic acidPersistent environmental contaminantsMetabolic profile
2022
Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment
Jia X, Jin Q, Fang J, Shi Y, Hou M, Dong H, Liu Y, Deng F, Zhou Y, Pollitt K, Tang S, Shi X, Cai Y. Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment. Environmental Science And Technology 2022, 56: 7905-7916. PMID: 35584234, DOI: 10.1021/acs.est.2c00381.Peer-Reviewed Original ResearchConceptsElderly adultsHealthy elderly adultsBw/dayHuman exposureAdverse health effectsMedian intakeIntake assessmentElderly populationMonth assessment periodDietary ingestionHealth effectsInternal exposureWhole bloodPerfluorooctanoic acidExposure levelsImportant exposure pathwayExposure assessmentAssessment periodConsecutive monthsRegression analysisPolyfluoroalkyl substancesPerfluorooctanesulfonic acidCl-PFESAExposureAdults