2024
Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea.
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnea. European Respiratory Journal 2024, 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionThe Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report.
Cohen O, Kundel V, Barbé F, Peker Y, McEvoy D, Sánchez-de-la-Torre M, Gottlieb D, Bradley T, Suárez-Fariñas M, Zinchuk A, Azarbarzin A, Malhotra A, Schotland H, Gozal D, Jelic S, Ramos A, Martin J, Pamidi S, Johnson D, Mehra R, Somers V, Hoyos C, Jackson C, Alcantara C, Billings M, Bhatt D, Patel S, Redline S, Yaggi H, Shah N. The Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science Through Expert Consensus. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024 PMID: 39513996, DOI: 10.1513/annalsats.202409-981st.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressureRandomized controlled trialsCardiovascular diseaseImpact of obstructive sleep apneaPrevalence of obstructive sleep apneaOSA subtypesSubgroup of OSA patientsObstructive sleep apnea syndromeObstructive sleep apnea treatmentIncidence of comorbid conditionsSleep apnea treatmentCardiovascular risk benefitMulti-modality therapeutic approachSleep clinic patientsPersonalized therapeutic strategiesTreat symptomatic patientsResponse to treatmentSecondary CVD eventsCost-effective diagnosisComposite CVD outcomeOSA patientsPAP adherenceSleep apneaAssessment of symptomsNovel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 28: 2005-2015. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAP0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flow
2023
Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotype
2022
0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA)
Sharma A, Byrne S, Deng A, Chu J, Sands S, Wellman A, Redeke N, Yaggi H, Zinchuk A. 0158 Risk perception, outcome expectancy, and treatment self-efficacy among women and men with obstructive sleep apnea (OSA). Sleep 2022, 45: a73-a73. DOI: 10.1093/sleep/zsac079.156.Peer-Reviewed Original ResearchOutcome expectanciesContinuous positive airway pressureObstructive sleep apneaSub-scale scoresRisk perceptionSelf-efficacy measuresCPAP adherenceIndividual risk perceptionInsomnia Severity Index scoreCPAP therapyEffectiveness of CPAPNon-CPAP therapiesUnstable medical conditionsCo-primary outcomesFirst-line therapyPositive airway pressureApnea-hypopnea indexSeverity Index scoreEpworth Sleepiness ScalePerceptionSex differencesCPAP useOSA severityAirway pressureDaytime symptoms
2021
342 CBT-I Has Sustained Effects on Insomnia Versus Heart-Failure Self-Management Education among Adults with Chronic Heart Failure
Redeker N, Bessette A, Breazeale S, Conley S, Hollenbeak C, Hwang Y, Iannacco J, Jacoby D, Kelly-Hauser J, Linsky S, Moemeka L, Nwanaji-Enwerem U, O’Connell M, Yaggi H, Jeon S. 342 CBT-I Has Sustained Effects on Insomnia Versus Heart-Failure Self-Management Education among Adults with Chronic Heart Failure. Sleep 2021, 44: a136-a137. DOI: 10.1093/sleep/zsab072.341.Peer-Reviewed Original ResearchChronic heart failurePittsburgh Sleep Quality IndexHeart failureSleep apneaSleep disturbance questionnaireHS groupInsomnia severityStable chronic heart failureContinuous positive airway pressureSelf-reported sleep durationCBT-I interventionPoor daytime functionMild sleep apneaPositive airway pressureSleep-related cognitionsSleep Quality IndexModerate-severe insomniaCognitive behavioral therapyAirway pressureDaytime symptomsDaytime functionClinical insomniaSleep ScaleMild insomniaSleep qualityTreatment-Emergent Central Sleep Apnea
Zinchuk A, Yaggi H. Treatment-Emergent Central Sleep Apnea. 2021, 85-102. DOI: 10.1007/978-3-030-57942-5_8.ChaptersTreatment-emergent central sleep apneaContinuous positive airway pressureCentral sleep apneaObstructive sleep apneaSleep apneaPositive airway pressureUpper airway collapsibilityUpper airway patencyMulti-modality therapyVentilatory control systemAirway collapsibilityAirway pressureOpioid useOSA patientsAirway patencyHeart failureAtrial fibrillationCarbonic anhydrase inhibitorsCentral sleepPoor adherenceOptimal treatmentSedative hypnoticsClinical careApneaMultifactorial nature
2010
Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack
Bravata DM, Concato J, Fried T, Ranjbar N, Sadarangani T, McClain V, Struve F, Zygmunt L, Knight HJ, Lo A, Richerson GB, Gorman M, Williams LS, Brass LM, Agostini J, Mohsenin V, Roux F, Yaggi HK. Auto-Titrating Continuous Positive Airway Pressure for Patients With Acute Transient Ischemic Attack. Stroke 2010, 41: 1464-1470. PMID: 20508184, PMCID: PMC4567557, DOI: 10.1161/strokeaha.109.566745.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsVascular event ratesIntervention patientsSleep apneaTIA patientsVascular eventsContinuous positive airway pressure (CPAP) adherenceAcute transient ischemic attackTransient ischemic attack patientsContinuous positive airway pressurePositive airway pressure adherenceEvent ratesTransient ischemic attackPositive airway pressureCongestive heart failureMajority of patientsSleep apnea patientsIschemic attackRecurrent TIAAirflow obstructionAirway pressureControl patientsCPAP useHeart failureMyocardial infarction