2024
Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model
Lagier D, Zeng C, Kaczka D, Zhu M, Grogg K, Gerard S, Reinhardt J, Ribeiro G, Rashid A, Winkler T, Vidal Melo M. Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model. Science Translational Medicine 2024, 16: eado1097. PMID: 39141699, DOI: 10.1126/scitranslmed.ado1097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomechanical PhenomenaLungPositive-Pressure RespirationPressureRespiration, ArtificialSheepTidal VolumeTomography, X-Ray ComputedConceptsPositive end-expiratory pressureMechanical ventilationFour-dimensional computed tomographyParenchymal strainsVentilator-induced lung injuryAcute respiratory distress syndromeRespiratory system driving pressureManagement of mechanical ventilationPositive end-expiratory pressure valuesRespiratory distress syndromeTidal overdistensionEnd-expiratory pressureAssociated with mortalityPulmonary complicationsLung biomechanicsLung massDistress syndromeClinical outcomesLung injuryComputed tomographyClinical managementGeneral anesthesiaLung collapseDriving pressureLung
2018
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Motta-Ribeiro G, Hashimoto S, Winkler T, Baron R, Grogg K, Paula L, Santos A, Zeng C, Hibbert K, Harris R, Bajwa E, Vidal Melo M. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 891-902. PMID: 29787304, PMCID: PMC6173064, DOI: 10.1164/rccm.201710-2038oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnalysis of VarianceAnimalsBiopsy, NeedleBlood Gas AnalysisDisease Models, AnimalEndotoxemiaEndotoxinsFemaleFluorodeoxyglucose F18HumansImmunohistochemistryInfusions, IntravenousLinear ModelsMultivariate AnalysisPositron-Emission TomographyPulmonary AtelectasisRandom AllocationRespiration, ArtificialRespiratory Distress SyndromeRespiratory Function TestsRisk FactorsSheepTidal VolumeTime FactorsTomography, X-Ray ComputedConceptsLung injurySupine lungConsistent with clinical practiceBlood volumeF-FDG phosphorylation rateLocal neutrophilic inflammationAssociated with increased inflammationF-FDG uptakeEarly mechanical ventilationClinical practiceEarly lung injuryPositive end-expiratory pressureLung strainEnd-expiratory pressurePositron emission tomographyF-FDGUninjured lungsImaging findingsRegional inflammationNeutrophilic inflammationSystemic endotoxemiaProne positionComputed tomographyVentilated patientsIntravenous endotoxin