2024
Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms
Rosovsky R, Mezue K, Gharios C, Civieri G, Cardeiro A, Zureigat H, Lau H, Pitman R, Shin L, Abohashem S, Osborne M, Jaffer F, Tawakol A. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms. American Journal Of Hematology 2024, 99: 1927-1938. PMID: 38965839, PMCID: PMC11502251, DOI: 10.1002/ajh.27427.Peer-Reviewed Original ResearchTreatment of anxietyAssociated with heightened riskDeep vein thrombosisNeural mechanismsHeart rate variabilityAutonomic system activityMediation analysisVein thrombosisHs-CRPNeural activityAnxietyDepressionCortical activityIncident deep vein thrombosisF-FDG PET/CT imagingHigh-sensitivity C-reactive proteinFemale participantsMedian follow-upC-reactive proteinDVT risk factorsMedian ageMass General Brigham BiobankRetrospective studyChronic inflammationFollow-upINSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY
Ye Z, Maayah M, Wang P, See C, Grubman S, Akhlaghi N, Allen S, Dong W, Ghare M, Gokhan I, Grubman D, Mezue K, Mottola G, Park D, Trejo-Paredes C, Shen M, Vemmou E, Abdullah A, Alaiwi S, Sharma S, Gupta N, Gandhi P, Wang Y, Kwan J, Hu J. INSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY. Journal Of The American College Of Cardiology 2024, 83: 2522. DOI: 10.1016/s0735-1097(24)04512-1.Peer-Reviewed Original ResearchEffect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effectsClinical Biochemistry of Serum Troponin
Gokhan I, Dong W, Grubman D, Mezue K, Yang D, Wang Y, Gandhi P, Kwan J, Hu J. Clinical Biochemistry of Serum Troponin. Diagnostics 2024, 14: 378. PMID: 38396417, PMCID: PMC10887818, DOI: 10.3390/diagnostics14040378.Peer-Reviewed Original ResearchAcute coronary syndromeFalse negative test resultsPoint of care assayInterpretation of serum levelsNegative test resultsTroponin complexChest painInterpretation of assay resultsSerum levelsClinical workupCoronary syndromeTn assaysMyocardial injuryTest characteristicsClinical settingCare assaysTroponinMeasurement assaysMolecular characteristicsPotential causesAssay resultsAssayMolecular structureFalse resultsConstituent proteins
2023
Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk
Mezue K, Abohashem S, Osborne M, Tawakol A. Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 82: e227-e228. PMID: 38030356, PMCID: PMC10752352, DOI: 10.1016/j.jacc.2023.09.825.Peer-Reviewed Original ResearchEXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA
SAEED G, OGUNMOLA I, OTITE F, LAMIKANRA O, OSONDU C, MEZUE K, FEHER A, YAGGI H, ANENI E. EXCESSIVE DAYTIME SLEEPINESS IS ASSOCIATED WITH INCIDENT HEART FAILURE IN A CLINICAL POPULATION WITH OBSTRUCTIVE SLEEP APNEA. CHEST Journal 2023, 164: a6312. DOI: 10.1016/j.chest.2023.07.4065.Peer-Reviewed Original ResearchUneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access
Madu E, Mezue K. Uneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access. BMC Global And Public Health 2023, 1: 15. DOI: 10.1186/s44263-023-00016-3.Peer-Reviewed Original ResearchTTR-CABlack populationHealthcare financing mechanismsPublic health budgetsCardiac amyloidosisGlobal health equityAt-risk populationsHeart failureHealth literacyHealth equityHealth workersTransthyretin cardiac amyloidosisHealth budgetDiastolic heart failureImprove accessPoor awarenessWest African ancestryDisease RegistryCenters of excellenceInternational Center of ExcellenceUneven burdenFinancial remunerationCaribbean populationGenetic basisAfrican ancestryReduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACEGenetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States
Mezue K, Driggin E. Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States. Journal Of Cardiac Failure 2023, 29: 1173-1174. PMID: 37062471, DOI: 10.1016/j.cardfail.2023.03.021.Peer-Reviewed Original ResearchFocused cardiac ultrasound in pregnancy
Edwards P, Anyaogu C, Mezue K, Baugh D, Goha A, Egbuche O, Nunura F, Madu E. Focused cardiac ultrasound in pregnancy. Journal Of Investigative Medicine 2023, 71: 81-91. PMID: 36691704, DOI: 10.1177/10815589221142195.Peer-Reviewed Original ResearchConceptsFocused cardiac ultrasoundRheumatic heart diseaseCardiac diseaseMaternal morbidityMaternal outcomesMaternal mortality review committeesHeart diseaseAssociated with poor maternal outcomeCause of maternal mortalityCardiac ultrasoundMortality Review CommitteePoor maternal outcomeSymptoms of normal pregnancyMiddle-income countriesExcessive maternal morbidityHigh-income countriesPoint of careAcquired cardiac diseaseManagement of cardiac diseaseMaternal mortalityEmergency medicineDiagnosis of cardiac diseaseNormal pregnancyTreatment of heart diseasePrompt recognition
2022
Myocardial Suppression Protocols
Osborne M, Mezue K, Divakaran S. Myocardial Suppression Protocols. 2022, 47-54. DOI: 10.1007/978-3-031-09807-9_4.Peer-Reviewed Original ResearchTreatment of inflammatory cardiovascular diseasesPatient preparation strategiesMyocardial glucose metabolismInflammatory cardiovascular diseasesPositron emission tomographyImaging techniquesInflammatory cellsPatient populationConsensus recommendationsPathological inflammationPatient preparationPharmacological interventionsEmission tomographyCardiovascular diseaseNormal myocardiumPatientsGlucose metabolismMyocardiumMetabolismInflammationDiagnosisTomographyGenetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events
Abohashem S, Osborne M, Choi K, Liu Z, Zureigat H, Mezue K, Gharios C, Armstrong K, Smoller J, Tawakol A. Genetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events. European Heart Journal 2022, 43: ehac544.2265. DOI: 10.1093/eurheartj/ehac544.2265.Peer-Reviewed Original ResearchLow socioeconomic statusArea Deprivation IndexSocioeconomic statusMajor adverse cardiovascular eventsRisk associated with low socioeconomic statusCardiovascular diseaseMass General Brigham BiobankPolygenic risk scoresYears of follow-upAssociation with incident major adverse cardiovascular eventsIncident major adverse cardiovascular eventsDeprivation indexHome addressAssociated with major adverse cardiovascular eventsMedian incomeRisk scoreRisk factorsMediation analysisAdverse cardiovascular eventsNeural pathwaysFunding sourcesFollow-upCardiovascular eventsStress sensitivityIndividualsFluid Restriction Recommendations in Heart Failure: Dry as a Bone or Quench Your Thirst?
Merlo A, Mezue K, Ambrosy A. Fluid Restriction Recommendations in Heart Failure: Dry as a Bone or Quench Your Thirst? Journal Of Cardiac Failure 2022, 28: 1531-1533. PMID: 35977689, DOI: 10.1016/j.cardfail.2022.07.054.Peer-Reviewed Original ResearchThe combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events
Osborne M, Abohashem S, Naddaf N, Abbasi T, Zureigat H, Mezue K, Ghoneem A, Dar T, Cardeiro A, Mehta N, Rajagopalan S, Fayad Z, Tawakol A. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. Journal Of Nuclear Cardiology 2022, 30: 665-679. PMID: 35915324, PMCID: PMC9889575, DOI: 10.1007/s12350-022-03003-7.Peer-Reviewed Original ResearchConceptsAir pollutionNoise exposureAverage air pollutionMajor adverse cardiovascular eventsTransportation noise exposureCardiovascular disease eventsPollutionRisk of cardiovascular disease eventsHigher exposuresDisease eventsIndividual residentsMajor adverse cardiovascular events riskActive cancerCardiovascular diseaseNoise pollutionAssociated with major adverse cardiovascular eventsAdverse cardiovascular eventsExposureF-FDG PET/CT imagingCardiovascular eventsRiskEffect of airAirArterial inflammationYearsPET myocardial perfusion imaging in superior vena cava syndrome
Mezue K, Chow D, Tawakol A, Fakhri G, Osborne M. PET myocardial perfusion imaging in superior vena cava syndrome. Journal Of Nuclear Cardiology 2022, 30: 1720-1724. PMID: 35764777, PMCID: PMC9794631, DOI: 10.1007/s12350-022-03033-1.Peer-Reviewed Original ResearchMolecular Imaging in Acute Aortic Syndrome Lighting a Path to Better Risk Assessment ∗
Tawakol A, Mezue K. Molecular Imaging in Acute Aortic Syndrome Lighting a Path to Better Risk Assessment ∗. JACC Cardiovascular Imaging 2022, 15: 1305-1307. PMID: 35798406, DOI: 10.1016/j.jcmg.2022.04.022.Peer-Reviewed Original ResearchImplantable Cardiac Defibrillator Lead Infective Endocarditis Due to Rothia Specie: A Rare Case in An Immunocompetent Man
A. C, Egbuche O, Nwokike S, Mezue K, Abe T, Bulsara K, Olanipekun T, Onuorah I. Implantable Cardiac Defibrillator Lead Infective Endocarditis Due to Rothia Specie: A Rare Case in An Immunocompetent Man. Reviews In Cardiovascular Medicine 2022, 23: 149. PMID: 39077620, PMCID: PMC11273638, DOI: 10.31083/j.rcm2305149.Peer-Reviewed Original ResearchCARDIOVASCULAR BENEFIT OF EXERCISE IS GREATER IN THOSE WITH ANXIETY AND DEPRESSION
Zureigat H, Abohashem S, Grewal S, Radfar A, Gharios C, Mezue K, Cardeiro A, Pitman R, Shin L, Baggish A, Osborne M, Tawakol A. CARDIOVASCULAR BENEFIT OF EXERCISE IS GREATER IN THOSE WITH ANXIETY AND DEPRESSION. Journal Of The American College Of Cardiology 2022, 79: 1436. DOI: 10.1016/s0735-1097(22)02427-5.Peer-Reviewed Original Research
2021
Moderate alcohol intake associates with a decreased risk of venous thrombosis: mediation through decreased stress-associated brain activity
Mezue K, Osborne M, Abbasi T, Zureigat H, Abohashem S, Gharios C, Akuffo E, Cardeiro A, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Moderate alcohol intake associates with a decreased risk of venous thrombosis: mediation through decreased stress-associated brain activity. European Heart Journal 2021, 42: ehab724.2046. DOI: 10.1093/eurheartj/ehab724.2046.Peer-Reviewed Original ResearchModerate alcohol intakeDeep venous thrombosisAlcohol intakeNeural activityEffects of alcoholEffects of moderate alcoholVenous thrombosisDecreased riskNeural effectsMedian follow-up periodDeep venous thrombosis riskBrain activityMediation analysisRisk of deep venous thrombosisIncidence of deep venous thrombosisRisk of venous thrombosisDecreased risk of venous thrombosisAdult participantsEmission tomography imagingCox regression analysisFollow-up periodNeural pathwaysNeurobiological activityFollow-up outcome informationModerate alcoholAnxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways
Mezue K, Osborne M, Abohashem S, Zureigat H, Abbasi T, Gharios C, Cardeiro A, Akuffo E, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Anxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways. European Heart Journal 2021, 42: ehab724.2045. DOI: 10.1093/eurheartj/ehab724.2045.Peer-Reviewed Original ResearchAnxiety disordersInternational Classification of DiseasesRisk of deep venous thrombosisDeep venous thrombosisNeural activityNeural pathwaysFollow-up periodMass General Brigham BiobankIncreased riskClassification of DiseasesBiobank enrollmentVenous thrombosisIncreased risk of DVTCancer historyIncreased risk of deep venous thrombosisHealth informationMediation analysisDeep venous thrombosis riskInternational ClassificationMedian follow-up periodPotential confoundersAnxietyLower extremity deep venous thrombosisExtremity deep venous thrombosisDepression