2024
Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effects
2023
Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACE
2020
Transvenous Retrieval of a Pulmonary Artery Catheter Knot Around Pacing Leads: A Case Report
Egbuche O, Nwagbara K, Mezue K, Abe T, Nwokike S. Transvenous Retrieval of a Pulmonary Artery Catheter Knot Around Pacing Leads: A Case Report. Cardiovascular Revascularization Medicine 2020, 28: 144-146. PMID: 33077395, DOI: 10.1016/j.carrev.2020.09.037.Peer-Reviewed Original ResearchConceptsPulmonary artery catheter insertionPulmonary artery catheterInsertion of pulmonary artery cathetersCardiac resynchronization therapyCatheter knottingBlind insertionSevere left ventricular systolic dysfunctionDilated right heart chambersPulmonary artery catheter knottingLeft ventricular systolic dysfunctionManagement of acute heart failureVentricular systolic dysfunctionArtery catheter insertionAcute heart failureRight heart chambersCardiac resynchronization devicesSystolic dysfunctionResynchronization therapyFluoroscopy-guided insertionDilated cardiomyopathyCatheter insertionArtery catheterHeart failureHemodynamic managementResynchronization devices
2018
Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictors
2017
Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial
Mezue K, Goyal A, Pressman G, Horrow J, Rangaswami J. Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial. American Journal Of Hypertension 2017, 31: 48-52. PMID: 28985328, DOI: 10.1093/ajh/hpx128.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute kidney injuryDiastolic blood pressureDBP CVVisit-to-visitCardiovascular outcomesBlood pressure variabilityAdverse eventsPrimary outcomeKidney diseaseBlood pressureAssociated with adverse cardiovascular outcomesVisit-to-visit blood pressure variabilityCox proportional hazards regressionTarget systolic blood pressureAdverse cardiovascular outcomesPressure variabilityProportional hazards regressionSystolic blood pressurePredicting adverse eventsPost hoc analysisVisit-to-visit DBP variabilityAntihypertensive therapyIndependent predictorsKidney injuryVisit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT
Goyal A, Mezue K, Rangaswami J. Visit‐to‐visit systolic blood pressure variability predicts treatment‐related adverse event of hyponatremia in SPRINT. Cardiovascular Therapeutics 2017, 35 PMID: 28544636, DOI: 10.1111/1755-5922.12274.Peer-Reviewed Original ResearchConceptsVisit-to-visit systolic blood pressure variabilitySystolic blood pressureSystolic blood pressure variabilityTarget blood pressureBlood pressureBlood pressure variabilitySPRINT trialAdverse eventsSystolic blood pressure <Occurrence of hyponatremiaCox proportional hazards regressionRisk of hyponatremiaBlood pressure <Coefficient of variation of systolic blood pressureProportional hazards regressionStandard treatment groupCardiovascular risk factorsPressure variabilityOverall cohortTreatment armsTreatment subgroupsHazards regressionInclusion criteriaCoefficient of variationHyponatremia
2016
Nocturnal Non-dipping Blood Pressure Profile in Black Normotensives Is Associated with Cardiac Target Organ Damage.
Mezue K, Isiguzo G, Madu C, Nwuruku G, Rangaswami J, Baugh D, Madu E. Nocturnal Non-dipping Blood Pressure Profile in Black Normotensives Is Associated with Cardiac Target Organ Damage. Ethnicity & Disease 2016, 26: 279-84. PMID: 27440966, PMCID: PMC4948793, DOI: 10.18865/ed.26.3.279.Peer-Reviewed Original ResearchConceptsCardiac target organ damageTarget organ damageNon-dippersBlood pressure profileNocturnal blood pressureOrgan damageBlood pressureBlack normotensivesNon-dipping of blood pressureMass indexCardiovascular riskLeft atrial volume indexLeft ventricular mass indexCardiovascular end-organ damageIncreased relative wall thicknessAtrial volume indexAmbulatory blood pressure patternsNon-dipper groupVentricular mass indexNocturnal non-dippingNon-dipping profileNon-dipping patternPredictor of cardiovascular riskEnd-organ damageNon-dipping blood pressure profileFactors that influence decision for ischemic work-up in hypertensive emergency
Maludum O, Shah M, Mezue K, Biso S, Rodriguez-Ziccardi M, Alnabelsi T, Nwakile C, Figueredo V. Factors that influence decision for ischemic work-up in hypertensive emergency. International Journal Of Cardiology 2016, 214: 331-332. PMID: 27085121, DOI: 10.1016/j.ijcard.2016.03.219.Peer-Reviewed Original ResearchQRS duration predicts left ventricular systolic function following ST elevation myocardial infarction
Maludum O, Nwakile C, Mezue K, Shah M, Purushottam B, Morris D, Figueredo V. QRS duration predicts left ventricular systolic function following ST elevation myocardial infarction. International Journal Of Cardiology 2016, 207: 300-302. PMID: 26814632, DOI: 10.1016/j.ijcard.2016.01.182.Peer-Reviewed Original Research
2010
Intractable Ventricular Tachycardia Secondary to Cardiac Hemangioma
Abu-Omar Y, Mezue K, Ali A, Kneeshaw J, Goddard M, Large S. Intractable Ventricular Tachycardia Secondary to Cardiac Hemangioma. The Annals Of Thoracic Surgery 2010, 90: 1347-1349. PMID: 20868844, DOI: 10.1016/j.athoracsur.2010.03.094.Peer-Reviewed Original ResearchConceptsVentricular tachycardiaLong-term medical therapyManagement of ventricular arrhythmiasIntractable ventricular tachycardiaCardiac tumorsSurgical resectionCardiac neoplasmsCardiac massSurgical treatmentMedical therapyMiddle-aged menVentricular arrhythmiasVentricular dysrhythmiasMedical managementTachycardiaSuccess rateDysrhythmiasResectionCryoablationHemangiomaNeoplasmsTumorTherapyArrhythmiasHistopathology