2024
Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiovascular DiseasesExerciseFemaleHumansMaleMiddle AgedNeural PathwaysPositron-Emission TomographyRisk FactorsTomography, X-Ray ComputedConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effects
2023
Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk
Mezue K, Abohashem S, Osborne M, Tawakol A. Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 82: e227-e228. PMID: 38030356, PMCID: PMC10752352, DOI: 10.1016/j.jacc.2023.09.825.Peer-Reviewed Original ResearchReduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesEthanolFemaleHeart Disease Risk FactorsHumansMaleMiddle AgedNeural Networks, ComputerRisk FactorsConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACE
2022
The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events
Osborne M, Abohashem S, Naddaf N, Abbasi T, Zureigat H, Mezue K, Ghoneem A, Dar T, Cardeiro A, Mehta N, Rajagopalan S, Fayad Z, Tawakol A. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. Journal Of Nuclear Cardiology 2022, 30: 665-679. PMID: 35915324, PMCID: PMC9889575, DOI: 10.1007/s12350-022-03003-7.Peer-Reviewed Original ResearchConceptsAir pollutionNoise exposureAverage air pollutionMajor adverse cardiovascular eventsTransportation noise exposureCardiovascular disease eventsPollutionRisk of cardiovascular disease eventsHigher exposuresDisease eventsIndividual residentsMajor adverse cardiovascular events riskActive cancerCardiovascular diseaseNoise pollutionAssociated with major adverse cardiovascular eventsAdverse cardiovascular eventsExposureF-FDG PET/CT imagingCardiovascular eventsRiskEffect of airAirArterial inflammationYears
2020
COVID‐19 and the heart: An update for clinicians
Goha A, Mezue K, Edwards P, Nunura F, Baugh D, Madu E. COVID‐19 and the heart: An update for clinicians. Clinical Cardiology 2020, 43: 1216-1222. PMID: 32533585, PMCID: PMC7323229, DOI: 10.1002/clc.23406.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCardiovascular DiseasesCoronavirus InfectionsCOVID-19HumansPandemicsPneumonia, ViralRenin-Angiotensin SystemRisk FactorsSARS-CoV-2ConceptsPrognosis of COVID-19 diseaseAdverse cardiac effectsPre-existing cardiovascular diseaseOptimal patient managementAcute myocardial injuryRisk of morbidityAcute coronary syndromeManifestations of COVID-19Cardiovascular manifestations of COVID-19Cardiovascular manifestationsCardiac effectsEffects of medicationVenous thromboembolismCoronary syndromeHeart failureMyocardial injuryPatient managementRAA systemClinical syndromeCardiovascular diseaseViral entrySARS-CoV-2COVID-19 diseaseHeartCOVID-19
2018
Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAntihypertensive AgentsBlood PressureBlood Pressure DeterminationCardiovascular DiseasesFemaleHumansHypertensionMaleRegression AnalysisRisk FactorsConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictors
2017
Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial
Mezue K, Goyal A, Pressman G, Horrow J, Rangaswami J. Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial. American Journal Of Hypertension 2017, 31: 48-52. PMID: 28985328, DOI: 10.1093/ajh/hpx128.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute kidney injuryDiastolic blood pressureDBP CVVisit-to-visitCardiovascular outcomesBlood pressure variabilityAdverse eventsPrimary outcomeKidney diseaseBlood pressureAssociated with adverse cardiovascular outcomesVisit-to-visit blood pressure variabilityCox proportional hazards regressionTarget systolic blood pressureAdverse cardiovascular outcomesPressure variabilityProportional hazards regressionSystolic blood pressurePredicting adverse eventsPost hoc analysisVisit-to-visit DBP variabilityAntihypertensive therapyIndependent predictorsKidney injuryDirectly Observed Therapy A Possible Tool to Tackle Medication Nonadherence in the CVD Epidemic
Mezue K, Rangaswami J. Directly Observed Therapy A Possible Tool to Tackle Medication Nonadherence in the CVD Epidemic. Journal Of The American College Of Cardiology 2017, 69: 3009. PMID: 28619202, DOI: 10.1016/j.jacc.2017.02.076.Peer-Reviewed Original Research