2024
Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effects
2023
Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk
Mezue K, Abohashem S, Osborne M, Tawakol A. Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 82: e227-e228. PMID: 38030356, PMCID: PMC10752352, DOI: 10.1016/j.jacc.2023.09.825.Peer-Reviewed Original ResearchReduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACE
2021
Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury
Egbuche O, Abe T, Nwokike S, Jegede O, Mezue K, Olanipekun T, Onuorah I, Echols M. Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury. Reviews In Cardiovascular Medicine 2021, 22: 1667-1675. PMID: 34957809, PMCID: PMC9054458, DOI: 10.31083/j.rcm2204174.Peer-Reviewed Original ResearchConceptsIn-hospital cardiac eventsCOVID-19 patientsIn-hospital mortalityCardiac eventsGrady Health SystemNon-blacksAssociated with increased disease burdenCardiopulmonary outcomesPolymerase-chain-reaction assayAssociated with higher riskMortality of hospitalized COVID-19 patientsAcute respiratory distress syndromeAssociated with worse outcomesIn-hospital acute kidney injuryMechanism of injuryOutcomes of hospitalized COVID-19 patientsPresence of AKIHospitalized COVID-19 patientsRespiratory distress syndromeProportion of patientsAcute kidney injuryPrimary composite outcomeRetrospective cohort studyImpact of AKIHealth system
2020
COVID‐19 and the heart: An update for clinicians
Goha A, Mezue K, Edwards P, Nunura F, Baugh D, Madu E. COVID‐19 and the heart: An update for clinicians. Clinical Cardiology 2020, 43: 1216-1222. PMID: 32533585, PMCID: PMC7323229, DOI: 10.1002/clc.23406.Peer-Reviewed Original ResearchConceptsPrognosis of COVID-19 diseaseAdverse cardiac effectsPre-existing cardiovascular diseaseOptimal patient managementAcute myocardial injuryRisk of morbidityAcute coronary syndromeManifestations of COVID-19Cardiovascular manifestations of COVID-19Cardiovascular manifestationsCardiac effectsEffects of medicationVenous thromboembolismCoronary syndromeHeart failureMyocardial injuryPatient managementRAA systemClinical syndromeCardiovascular diseaseViral entrySARS-CoV-2COVID-19 diseaseHeartCOVID-19
2018
Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictorsBlood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis
Kanjanahattakij N, Horn B, Abdulhadi B, Wongjarupong N, Mezue K, Rattanawong P. Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis. Journal Of Artificial Organs 2018, 21: 271-277. PMID: 29546615, DOI: 10.1007/s10047-018-1034-5.Peer-Reviewed Original ResearchMeSH KeywordsBacteremiaCatheter-Related InfectionsHeart-Assist DevicesHumansRetrospective StudiesRisk FactorsStrokeConceptsBlood stream infectionsLeft ventricular assist deviceIschemic cerebrovascular accidentCerebrovascular accidentPost-left ventricular assist deviceMeta-analysisAssociated with cerebrovascular accidentsVentricular assist deviceStudy assessed patientsEMBASE electronic databasesHemorrhagic cerebrovascular accidentPooled effect sizeRandom-effects modelInverse of varianceHeart failureIncreased incidenceAssist devicePatientsElectronic databasesSystematic reviewEffect sizeMinimal heterogeneityInfectionBloodMultiple studies
2017
Acute kidney injury post–transcatheter aortic valve replacement
Ram P, Mezue K, Pressman G, Rangaswami J. Acute kidney injury post–transcatheter aortic valve replacement. Clinical Cardiology 2017, 40: 1357-1362. PMID: 29251358, PMCID: PMC6490570, DOI: 10.1002/clc.22820.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAcute kidney injuryImpact of acute kidney injuryIntermediate-risk patientsPatient outcomesAortic valve replacementSevere aortic stenosisHigh-risk patientsCost of hospital stayReduce procedural complicationsPeriprocedural hydrationSurgical candidatesValve replacementAortic stenosisImprove patient outcomesBlood transfusionHemodynamic instabilityProcedural complicationsHospital stayKidney injuryPeriprocedural embolizationTreatment optionsDevice implantationPrevent embolizationContrast mediumBlood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial
Mezue K, Goyal A, Pressman G, Horrow J, Rangaswami J. Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial. American Journal Of Hypertension 2017, 31: 48-52. PMID: 28985328, DOI: 10.1093/ajh/hpx128.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute kidney injuryDiastolic blood pressureDBP CVVisit-to-visitCardiovascular outcomesBlood pressure variabilityAdverse eventsPrimary outcomeKidney diseaseBlood pressureAssociated with adverse cardiovascular outcomesVisit-to-visit blood pressure variabilityCox proportional hazards regressionTarget systolic blood pressureAdverse cardiovascular outcomesPressure variabilityProportional hazards regressionSystolic blood pressurePredicting adverse eventsPost hoc analysisVisit-to-visit DBP variabilityAntihypertensive therapyIndependent predictorsKidney injuryNovel Oral Anticoagulants in Atrial Fibrillation: Update on Apixaban
Mezue K, Obiagwu C, John J, Sharma A, Yang F, Shani J. Novel Oral Anticoagulants in Atrial Fibrillation: Update on Apixaban. Current Cardiology Reviews 2017, 13: 41-46. PMID: 27450450, PMCID: PMC5324317, DOI: 10.2174/1573403x12666160720092024.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticoagulantsEmbolismHemorrhageHumansPyrazolesPyridonesRisk FactorsStrokeConceptsFood and Drug AdministrationAtrial fibrillationReversal agentsClinical trialsNon-valvular atrial fibrillationSignificant mitral stenosisNovel oral anticoagulantsUS Food and Drug AdministrationOnset of actionPrimary safety outcomeClinical trial dataPrevention of strokeRate of strokeInhibitors of factor XaProsthetic heart valvesClinical bleedingApixaban useSystemic embolismOral anticoagulantsINR monitoringMitral stenosisDose variabilityNOACsApixabanCardiac arrhythmias
2016
Factors that influence decision for ischemic work-up in hypertensive emergency
Maludum O, Shah M, Mezue K, Biso S, Rodriguez-Ziccardi M, Alnabelsi T, Nwakile C, Figueredo V. Factors that influence decision for ischemic work-up in hypertensive emergency. International Journal Of Cardiology 2016, 214: 331-332. PMID: 27085121, DOI: 10.1016/j.ijcard.2016.03.219.Peer-Reviewed Original Research
2013
The increasing burden of hypertension in Nigeria – can a dietary salt reduction strategy change the trend?
Mezue K. The increasing burden of hypertension in Nigeria – can a dietary salt reduction strategy change the trend? Perspectives In Public Health 2013, 134: 346-352. PMID: 24002906, DOI: 10.1177/1757913913499658.Peer-Reviewed Original ResearchConceptsBurden of hypertensionIncreasing burden of hypertensionNon-communicable diseasesSalt reductionMiddle-income countriesPrevalence of hypertensionSalt reduction strategiesPopulation-wide basisPopulation-wide levelIncreasing burdenCardiovascular diseaseHypertensionReduction strategiesDeveloping countriesMortality