2024
Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effects
2021
Moderate alcohol intake associates with a decreased risk of venous thrombosis: mediation through decreased stress-associated brain activity
Mezue K, Osborne M, Abbasi T, Zureigat H, Abohashem S, Gharios C, Akuffo E, Cardeiro A, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Moderate alcohol intake associates with a decreased risk of venous thrombosis: mediation through decreased stress-associated brain activity. European Heart Journal 2021, 42: ehab724.2046. DOI: 10.1093/eurheartj/ehab724.2046.Peer-Reviewed Original ResearchModerate alcohol intakeDeep venous thrombosisAlcohol intakeNeural activityEffects of alcoholEffects of moderate alcoholVenous thrombosisDecreased riskNeural effectsMedian follow-up periodDeep venous thrombosis riskBrain activityMediation analysisRisk of deep venous thrombosisIncidence of deep venous thrombosisRisk of venous thrombosisDecreased risk of venous thrombosisAdult participantsEmission tomography imagingCox regression analysisFollow-up periodNeural pathwaysNeurobiological activityFollow-up outcome informationModerate alcohol