2023
Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACE
2022
Genetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events
Abohashem S, Osborne M, Choi K, Liu Z, Zureigat H, Mezue K, Gharios C, Armstrong K, Smoller J, Tawakol A. Genetic sensitivity to stress modifies the relationship between socioeconomic status and major adverse cardiovascular events. European Heart Journal 2022, 43: ehac544.2265. DOI: 10.1093/eurheartj/ehac544.2265.Peer-Reviewed Original ResearchLow socioeconomic statusArea Deprivation IndexSocioeconomic statusMajor adverse cardiovascular eventsRisk associated with low socioeconomic statusCardiovascular diseaseMass General Brigham BiobankPolygenic risk scoresYears of follow-upAssociation with incident major adverse cardiovascular eventsIncident major adverse cardiovascular eventsDeprivation indexHome addressAssociated with major adverse cardiovascular eventsMedian incomeRisk scoreRisk factorsMediation analysisAdverse cardiovascular eventsNeural pathwaysFunding sourcesFollow-upCardiovascular eventsStress sensitivityIndividualsThe combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events
Osborne M, Abohashem S, Naddaf N, Abbasi T, Zureigat H, Mezue K, Ghoneem A, Dar T, Cardeiro A, Mehta N, Rajagopalan S, Fayad Z, Tawakol A. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. Journal Of Nuclear Cardiology 2022, 30: 665-679. PMID: 35915324, PMCID: PMC9889575, DOI: 10.1007/s12350-022-03003-7.Peer-Reviewed Original ResearchConceptsAir pollutionNoise exposureAverage air pollutionMajor adverse cardiovascular eventsTransportation noise exposureCardiovascular disease eventsPollutionRisk of cardiovascular disease eventsHigher exposuresDisease eventsIndividual residentsMajor adverse cardiovascular events riskActive cancerCardiovascular diseaseNoise pollutionAssociated with major adverse cardiovascular eventsAdverse cardiovascular eventsExposureF-FDG PET/CT imagingCardiovascular eventsRiskEffect of airAirArterial inflammationYears