Pre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection.
Egbuche O, Jegede O, Abe T, Wagle B, Huynh K, Hayes D, Campbell M, Mezue K, Ram P, Nwokike S, Desai R, Effoe V, Kpodonu J, Morgan J, Ofili E, Onwuanyi A, Echols M. Pre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection. Am J Cardiovasc Dis 2021, 11: 212-221. PMID: 34084656, PMCID: PMC8166582.Peer-Reviewed Original ResearchIn-hospital cardiac eventsPre-existing cardiovascular diseaseAcute kidney injuryIn-hospital mortalityAcute respiratory distress syndromeAssociated with increased oddsCardiac eventsCOVID-19 patientsKidney injuryPresence of acute kidney injuryAssociated with increased odds of in-hospital mortalityPolymerase-chain-reaction assayHigher risk of in-hospital mortalityIn-hospital acute kidney injuryAssociated with worse outcomesRisk of in-hospital mortalityCardiovascular diseaseHospitalized COVID-19 patientsRespiratory distress syndromeOdds of in-hospital mortalityAssociated with higher riskRetrospective cohort studyMortality of COVID-19 patientsIn-hospital mortality of COVID-19 patientsDistress syndromeEfficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials.
Eze P, Mezue K, Nduka C, Obianyo I, Egbuche O. Efficacy and safety of chloroquine and hydroxychloroquine for treatment of COVID-19 patients-a systematic review and meta-analysis of randomized controlled trials. Am J Cardiovasc Dis 2021, 11: 93-107. PMID: 33815925, PMCID: PMC8012280.Peer-Reviewed Original ResearchRandomized clinical trialsStandard supportive therapyAdverse eventsSupportive therapyMeta-analysis of randomized controlled trialsPublished randomized clinical trialsMeta-analysisSevere adverse eventsSafety of CQSafety of chloroquineJoanna Briggs Institute DatabaseCochrane Collaboration assessment toolTreatment of COVID-19 patientsChinese Clinical Trial RegistryClinical Trials RegistryRandom-effects modelSub-group analysisRandomized controlled trialsCOVID-19 patientsRisk of biasMortality meta-analysisIn vivo studiesEfficacy outcomesInstitutional databaseMortality benefitRacial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury
Egbuche O, Abe T, Nwokike S, Jegede O, Mezue K, Olanipekun T, Onuorah I, Echols M. Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury. Reviews In Cardiovascular Medicine 2021, 22: 1667-1675. PMID: 34957809, PMCID: PMC9054458, DOI: 10.31083/j.rcm2204174.Peer-Reviewed Original ResearchConceptsIn-hospital cardiac eventsCOVID-19 patientsIn-hospital mortalityCardiac eventsGrady Health SystemNon-blacksAssociated with increased disease burdenCardiopulmonary outcomesPolymerase-chain-reaction assayAssociated with higher riskMortality of hospitalized COVID-19 patientsAcute respiratory distress syndromeAssociated with worse outcomesIn-hospital acute kidney injuryMechanism of injuryOutcomes of hospitalized COVID-19 patientsPresence of AKIHospitalized COVID-19 patientsRespiratory distress syndromeProportion of patientsAcute kidney injuryPrimary composite outcomeRetrospective cohort studyImpact of AKIHealth system