2012
Impaired olfaction and other prodromal features in the Parkinson At‐Risk Syndrome study
Siderowf A, Jennings D, Eberly S, Oakes D, Hawkins KA, Ascherio A, Stern MB, Marek K, Investigators T. Impaired olfaction and other prodromal features in the Parkinson At‐Risk Syndrome study. Movement Disorders 2012, 27: 406-412. PMID: 22237833, PMCID: PMC6342466, DOI: 10.1002/mds.24892.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesConstipationFemaleHumansMaleMiddle AgedMood DisordersOlfaction DisordersParkinson DiseaseRisk FactorsConceptsNonmotor featuresProdromal featuresOlfactory testingRapid eye movement sleep behaviour disorder symptomsSyndrome StudyPennsylvania Smell Identification TestDopamine transporter imagingPercent of subjectsSmell Identification TestRisk of PDFuture neurodegenerationHyposmic subjectsOlfactory dysfunctionImpaired olfactionTransporter imagingMotor functionMotor featuresSmell testNeurological diagnosisUndiagnosed individualsHyposmiaScreening testSpecific markersDisorder symptomsFurther assessment
2003
The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis II. Baseline characteristics of the “prodromal” sample
Miller TJ, Zipursky RB, Perkins D, Addington J, Woods SW, Hawkins KA, Hoffman R, Preda A, Epstein I, Addington D, Lindborg S, Marquez E, Tohen M, Breier A, McGlashan TH. The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis II. Baseline characteristics of the “prodromal” sample. Schizophrenia Research 2003, 61: 19-30. PMID: 12648732, DOI: 10.1016/s0920-9964(02)00440-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntipsychotic AgentsBenzodiazepinesBipolar DisorderComorbidityDepressive Disorder, MajorDouble-Blind MethodFemaleHumansMaleMood DisordersOlanzapinePirenzepinePsychomotor DisordersPsychotic DisordersRisk FactorsSchizophreniaSchizophrenic PsychologySleep Wake DisordersSpeech DisordersConceptsFirst-episode schizophreniaEpisode schizophreniaTreatment-seeking patientsClinical trialsDouble-blind placebo-controlled clinical trialProdromal SyndromesDouble-blind clinical trialPlacebo-controlled clinical trialAtypical neuroleptic medicationsMild affective symptomsNew diagnostic criteriaSerious mental illnessClinical trial samplesUntreated first-episode schizophreniaSubstance use/abuseEffects of drugsPutative prodromal syndromeUse/abuseUnusual thought contentAdolescent maniaOngoing symptomatologyProdromal sampleStudy medicationBaseline characteristicsMost patients