2019
Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses
Ovadia C, Seed PT, Sklavounos A, Geenes V, Di Illio C, Chambers J, Kohari K, Bacq Y, Bozkurt N, Brun-Furrer R, Bull L, Estiú MC, Grymowicz M, Gunaydin B, Hague WM, Haslinger C, Hu Y, Kawakita T, Kebapcilar AG, Kebapcilar L, Kondrackienė J, Koster MPH, Kowalska-Kańka A, Kupčinskas L, Lee RH, Locatelli A, Macias RIR, Marschall HU, Oudijk MA, Raz Y, Rimon E, Shan D, Shao Y, Tribe R, Tripodi V, Abide C, Yenidede I, Thornton JG, Chappell LC, Williamson C. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses. The Lancet 2019, 393: 899-909. PMID: 30773280, PMCID: PMC6396441, DOI: 10.1016/s0140-6736(18)31877-4.Peer-Reviewed Original ResearchMeSH KeywordsAlanine TransaminaseAspartate AminotransferasesBile Acids and SaltsBilirubinBiomarkersCase-Control StudiesCholestasis, IntrahepaticCohort StudiesFemaleHumansInfant, NewbornPerinatal DeathPregnancyPregnancy ComplicationsPremature BirthRandomized Controlled Trials as TopicRisk FactorsROC CurveStillbirthConceptsSerum bile acid concentrationsBile acid concentrationsIndividual patient dataAdverse perinatal outcomesRisk of stillbirthPerinatal outcomesTotal bile acidsIntrahepatic cholestasisSingleton pregnanciesBile acidsBiochemical markersPregnancy casesHigh riskSerum total bile acidsTotal bile acid concentrationAdverse perinatal effectsPatient dataElevated bile acid concentrationsPopulation-based studyCase-control studyPrevalence of stillbirthUK National InstituteStepwise logistic regressionSpecific biochemical markersFull-text articles
2016
Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy
Kohari KS, Carroll R, Capogna S, Ditchik A, Fox NS, Ferrara LA. Outcome after implementation of a modern management strategy for intrahepatic cholestasis of pregnancy. The Journal Of Maternal-Fetal & Neonatal Medicine 2016, 30: 1342-1346. PMID: 27418248, DOI: 10.1080/14767058.2016.1212833.Peer-Reviewed Original ResearchConceptsNeonatal outcomesIntrahepatic cholestasisBile acidsContinuous fetal heart rate monitoringModern management strategiesGreater maternal ageRetrospective cohort studyFetal heart rate monitoringCesarean delivery rateTotal bile acidsNew management protocolNew cohortNICU admissionGestational diabetesSingleton gestationsCohort studyPatient demographicsPregnancy outcomesInpatient admissionsMaternal ageHeart rate monitoringStillbirth rateWeeksCholestasisOutcomesMitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy
Mella MT, Kohari K, Jones R, Peña J, Ferrara L, Stone J, Lambertini L. Mitochondrial gene expression profiles are associated with intrahepatic cholestasis of pregnancy. Placenta 2016, 45: 16-23. PMID: 27577705, DOI: 10.1016/j.placenta.2016.07.002.Peer-Reviewed Original ResearchConceptsOxidative stress statusIntrahepatic cholestasisHepatic bile acid accumulationHigher maternal serum levelsMaternal serum levelsSpontaneous preterm birthNon-pregnant stateBile acid levelsBile acid concentrationsBile acid accumulationStress statusPathophysiology of ICPOxidative stress ratePreterm birthClinical courseFetal demiseSerum levelsFetal effectsPregnant womenHigh oxidative stressReal-time PCRLong-term effectsMitochondrial activityPlacenta samplesBile acids