2021
Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018
Chouairi F, Mullan CW, Ravindra N, Clark KAA, Jaffe EM, Bhinder J, Fuery M, Guha A, Ahmad T, Desai NR. Brief report: Cannabis and opioid use disorder among heart failure admissions, 2008–2018. PLOS ONE 2021, 16: e0255514. PMID: 34591847, PMCID: PMC8483306, DOI: 10.1371/journal.pone.0255514.Peer-Reviewed Original ResearchEvaluation of Racial and Ethnic Disparities in Cardiac Transplantation
Chouairi F, Fuery M, Clark KA, Mullan CW, Stewart J, Caraballo C, Clarke J, Sen S, Guha A, Ibrahim NE, Cole RT, Holaday L, Anwer M, Geirsson A, Rogers JG, Velazquez EJ, Desai NR, Ahmad T, Miller PE. Evaluation of Racial and Ethnic Disparities in Cardiac Transplantation. Journal Of The American Heart Association 2021, 10: e021067. PMID: 34431324, PMCID: PMC8649228, DOI: 10.1161/jaha.120.021067.Peer-Reviewed Original ResearchConceptsWhite patientsHispanic patientsBlack patientsCardiac transplantationHeart transplantationHigh riskEthnic disparitiesAdult heart recipientsAllocation system changePost-transplant deathPost-transplant mortalityOrgan Sharing databasePost-transplantation deathNew allocation systemHeart recipientsDiabetes mellitusRenal diseaseSharing databaseTransplantation ratesUnited NetworkContemporary outcomesPatientsTransplantationDonor characteristicsStudy periodComparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation
Kay B, Chouairi F, Clark KAA, Reinhardt SW, Fuery M, Guha A, Ahmad T, Kaple RK, Desai NR. Comparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation. Mayo Clinic Proceedings 2021, 96: 1522-1529. PMID: 34088415, DOI: 10.1016/j.mayocp.2021.01.029.Peer-Reviewed Original ResearchConceptsMitral valve repairMitral regurgitationValve repairInternational ClassificationPatient underwent mitral valve repairOpen mitral valve repairUnderwent mitral valve repairTranscatheter mitral valve repairStudy periodComparison of transcatheterProhibitive surgical riskTenth Revision codesTotal hospital chargesDegenerative mitral regurgitationNational Inpatient SampleLength of stayTranscatheter mitral valve repair deviceDischarge homeHospital mortalityDischarge dispositionPatient comorbiditiesSurgical riskHospital chargesMedian lengthNinth RevisionImpact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies
Chouairi F, Mullan CW, Sen S, Mori M, Fuery M, Elder RW, Lesse J, Norton K, Clark KA, Miller PE, Mulligan D, Formica R, Rogers JG, Jacoby D, Maulion C, Anwer M, Geirsson A, Desai NR, Ahmad T. Impact of the new heart allocation policy on patients with restrictive, hypertrophic, or congenital cardiomyopathies. PLOS ONE 2021, 16: e0247789. PMID: 33651802, PMCID: PMC7924739, DOI: 10.1371/journal.pone.0247789.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseAllocation system changeHeart allocation systemNew heart allocation policyNew heart allocation systemTransplantation of patientsOrgan Sharing databasePost-transplantation outcomesPost-transplant survivalTime of transplantationMechanical circulatory supportRate of transplantationNumber of patientsHeart allocation policyNew allocation systemStatus 1ACardiac transplantAdult patientsSharing databaseWaitlist survivalCirculatory supportClinical benefitCongenital cardiomyopathyUnited NetworkCHD patients
2017
Concurrent Central Venous Stent and Central Venous Access Device Placement Does Not Compromise Stent Patency or Catheter Function in Patients with Malignant Central Venous Obstruction
Clark K, Chick J, Reddy S, Shin B, Nadolski G, Clark T, Trerotola S. Concurrent Central Venous Stent and Central Venous Access Device Placement Does Not Compromise Stent Patency or Catheter Function in Patients with Malignant Central Venous Obstruction. Journal Of Vascular And Interventional Radiology 2017, 28: 602-607. PMID: 28238580, DOI: 10.1016/j.jvir.2016.12.1222.Peer-Reviewed Original ResearchConceptsCentral venous access devicesCentral venous obstructionCatheter functionStent patencyStent stenosisVenous obstructionClinical symptomsVenous stentsType of CVADCentral venous access device placementControl groupSuperior vena cava syndromeRecurrent clinical symptomsVena cava syndromeVenous access devicesCVAD placementStent revisionSymptomatic stenosisConsecutive patientsPatientsMalignant compressionStenosisPatencyDevice placementClinical performance
2013
Intracellular signaling mechanisms associated with CD47 modified surfaces
Finley M, Clark K, Alferiev I, Levy R, Stachelek S. Intracellular signaling mechanisms associated with CD47 modified surfaces. Biomaterials 2013, 34: 8640-8649. PMID: 23948164, PMCID: PMC3804223, DOI: 10.1016/j.biomaterials.2013.07.088.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBloodCD47 AntigenChemokinesCytokinesDown-RegulationFemaleHumansJanus Kinase 2MaleMatrix Metalloproteinase 1Matrix Metalloproteinase 13Matrix Metalloproteinase 7Middle AgedPolyvinyl ChlorideSignal TransductionSTAT Transcription FactorsTranscription, GeneticTranscriptional ActivationUp-RegulationYoung AdultConceptsTranscription factor bindingDifferential molecular responsesJAK/STATChromatin associationCell signaling levelsSynthetic polymeric surfacesTranscriptional changesFactor bindingDownregulation of cytokinesJAK-STATRelated genesUpregulation of MMPsInflammatory cell responseExposure of bloodInflammatory cell interactionsMolecular responseTranscriptionQPCR arrayCell interactionsInflammatory responseHuman whole bloodCell responsesCD47BloodWhole bloodAngina Pectoris or Myocardial Infarctions, Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Paradoxical Emboli
Clark K, Pyeritz R, Trerotola S. Angina Pectoris or Myocardial Infarctions, Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia, and Paradoxical Emboli. The American Journal Of Cardiology 2013, 112: 731-734. PMID: 23707042, DOI: 10.1016/j.amjcard.2013.04.052.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngina PectorisArteriovenous MalformationsChildChild, PreschoolEmbolism, ParadoxicalEmbolization, TherapeuticFemaleHumansMaleMiddle AgedMyocardial InfarctionMyocardial IschemiaPulmonary ArteryPulmonary VeinsRetrospective StudiesSelf ReportTelangiectasia, Hereditary HemorrhagicYoung AdultConceptsPulmonary arteriovenous malformationsParadoxical emboliHereditary hemorrhagic telangiectasiaCoronary arteryMyocardial infarctionArteriovenous malformationsHemorrhagic telangiectasiaSingle-center populationNormal coronary arteriesTransient ischemic attackCardiac ischemic eventsUntreated pulmonary arteriovenous malformationsSingle artery occlusionAutosomal dominant disorderCardiopulmonary symptomsIschemic attackChest painArtery occlusionIschemic eventsAngina pectorisCardiac catheterizationClinical complicationsVascular malformationsCardiac ischemiaPatients