2019
Lipid Modifications in Cilia Biology
Roy K, Marin EP. Lipid Modifications in Cilia Biology. Journal Of Clinical Medicine 2019, 8: 921. PMID: 31252577, PMCID: PMC6678300, DOI: 10.3390/jcm8070921.BooksLipid modificationCiliary proteinsCiliary protein traffickingSpecific protein poolsDifferent lipid modificationsCilia biologyProtein traffickingProtein stabilitySignaling cascadesTransporter proteinsProtein poolProteinVariety of rolesCiliaTraffickingFinal localizationCellular structureDistinctive roleBiologyRoleAbundanceModificationRegulationPathwayCascade
2017
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation
Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP. Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. Journal Of Biological Chemistry 2017, 292: 17703-17717. PMID: 28848045, PMCID: PMC5663873, DOI: 10.1074/jbc.m117.792937.Peer-Reviewed Original ResearchConceptsPost-translational attachmentMost mammalian cellsCiliary GTPase Arl13bCilia localizationProtein palmitoylationCiliary proteinsCilia proteinsProtein localizationCilia formationMammalian cellsCilia functionPalmitoylationPrimary ciliaPlasma membraneCilia resorptionArl13bFunctional importanceMyristoylationCiliaCritical roleProteinMouse kidneyLocalizationDepalmitoylationCellsCellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario
Majumder P, Roy K, Singh BK, Jana NR, Mukhopadhyay D. Cellular levels of Grb2 and cytoskeleton stability are correlated in a neurodegenerative scenario. Disease Models & Mechanisms 2017, 10: 655-669. PMID: 28360125, PMCID: PMC5451165, DOI: 10.1242/dmm.027748.Peer-Reviewed Original ResearchConceptsAD-like conditionsDisease manifestCytoskeletal architecturePak1 proteinCytoskeleton stabilityAD mouse brainCytoskeletal proteinsGrb2 overexpressionGrb2Β-amyloid oligomersPotential new strategyCellular levelNeuronal lossAD patientsPreventive roleCytoskeletonProteinMouse brainBrain tissueExtracellular accumulationPotent inducerMolecular featuresUnique roleDomain levelCytoskeletal
2014
Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s disease–like scenario
Roy K, Chakrabarti O, Mukhopadhyay D. Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s disease–like scenario. Biochemistry And Cell Biology 2014, 92: 219-225. PMID: 24882360, DOI: 10.1139/bcb-2014-0001.Peer-Reviewed Original ResearchConceptsSrc homology 3SH3 domainGrowth factor receptor-bound protein 2Receptor-bound protein 2C-terminal SH3 domainIntracellular domain interactionsN-terminal SH3 domainRole of Grb2Autophagic maturationHomology 3Actin remodelingAdaptor proteinCellular compartmentalizationGrb2Cell line modelsDomain interactionsGene proteinProtein 2ProteinAutophagosomesExcess conditionsVesiclesDomainCompartmentalizationMotif
2013
Differential Expression of Neuroblastoma Cellular Proteome due to AICD Overexpression
Chakrabarti A, Roy K, Mukhopadhyay D. Differential Expression of Neuroblastoma Cellular Proteome due to AICD Overexpression. Journal Of Alzheimer's Disease 2013, 38: 845-855. PMID: 24081375, DOI: 10.3233/jad-130695.Peer-Reviewed Original ResearchConceptsAmyloid-β protein precursor intracellular domainCell linesProteomic expression patternsDifferent functional classesCellular proteomeCytoskeletal dynamicsProtein foldingIntracellular domainExpression patternsBiological processesBiological pathwaysMALDI-MS identificationNormal proteomeDifferential expressionSHSY5Y cell lineNeuroblastoma cell linesKey playersProteomeAlzheimer's diseaseProtein overloadArtifactual consequenceProteinAD-like conditionsAD phenotypePathophysiological effects