2014
Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s disease–like scenario
Roy K, Chakrabarti O, Mukhopadhyay D. Interaction of Grb2 SH3 domain with UVRAG in an Alzheimer’s disease–like scenario. Biochemistry And Cell Biology 2014, 92: 219-225. PMID: 24882360, DOI: 10.1139/bcb-2014-0001.Peer-Reviewed Original ResearchConceptsSrc homology 3SH3 domainGrowth factor receptor-bound protein 2Receptor-bound protein 2C-terminal SH3 domainIntracellular domain interactionsN-terminal SH3 domainRole of Grb2Autophagic maturationHomology 3Actin remodelingAdaptor proteinCellular compartmentalizationGrb2Cell line modelsDomain interactionsGene proteinProtein 2ProteinAutophagosomesExcess conditionsVesiclesDomainCompartmentalizationMotif
2012
The N-Terminal SH3 Domain of Grb2 is Required for Endosomal Localization of AβPP
Raychaudhuri M, Roy K, Das S, Mukhopadhyay D. The N-Terminal SH3 Domain of Grb2 is Required for Endosomal Localization of AβPP. Journal Of Alzheimer's Disease 2012, 32: 479-493. PMID: 22785391, DOI: 10.3233/jad-2012-120388.Peer-Reviewed Original ResearchConceptsN-SH3 domainSH3 domainLate endosomesC-terminal SH3 domainC-SH3 domainN-terminal SH3 domainTerminal SH3 domainAmyloid-β protein precursorSH2 domainEndosomal localizationEarly endosomesVesicular localizationMolecular basisGrb2Mutational analysisTrafficking routesExosomal releaseProtein precursorExosomal vesiclesSmall punctaEndosomesTraffic impairmentEndogenous levelsVesiclesMixed population