The N-Terminal SH3 Domain of Grb2 is Required for Endosomal Localization of AβPP
Raychaudhuri M, Roy K, Das S, Mukhopadhyay D. The N-Terminal SH3 Domain of Grb2 is Required for Endosomal Localization of AβPP. Journal Of Alzheimer's Disease 2012, 32: 479-493. PMID: 22785391, DOI: 10.3233/jad-2012-120388.Peer-Reviewed Original ResearchConceptsN-SH3 domainSH3 domainLate endosomesC-terminal SH3 domainC-SH3 domainN-terminal SH3 domainTerminal SH3 domainAmyloid-β protein precursorSH2 domainEndosomal localizationEarly endosomesVesicular localizationMolecular basisGrb2Mutational analysisTrafficking routesExosomal releaseProtein precursorExosomal vesiclesSmall punctaEndosomesTraffic impairmentEndogenous levelsVesiclesMixed population