2019
Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer’s disease and type 2 diabetes
Majumder P, Roy K, Bagh S, Mukhopadhyay D. Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer’s disease and type 2 diabetes. Molecular And Cellular Biochemistry 2019, 459: 171-182. PMID: 31154588, DOI: 10.1007/s11010-019-03560-5.Peer-Reviewed Original ResearchConceptsType 2 diabetesAlzheimer's diseaseReceptor tyrosine kinasesPost-mortem Alzheimer's diseaseFuture therapeutic developmentInsulin resistanceDisease typeActivity statusDiseaseCommon hallmarkTherapeutic developmentDefinitive roleDiabetesOne-thirdTyrosine kinaseCell modelSimilar regulatory mechanismsT2D.Regulatory mechanisms
2018
Polycystin-1, the product of the polycystic kidney disease gene PKD1, is post-translationally modified by palmitoylation
Roy K, Marin EP. Polycystin-1, the product of the polycystic kidney disease gene PKD1, is post-translationally modified by palmitoylation. Molecular Biology Reports 2018, 45: 1515-1521. PMID: 30073588, DOI: 10.1007/s11033-018-4224-6.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseaseProteins polycystin-1End-stage renal diseasePossible pharmacologic targetsStage renal diseasePossible modifiable factorsRate of progressionDominant polycystic kidney diseaseExpression levelsPolycystic kidney diseaseRenal diseaseKidney diseaseModifiable factorsCommon causePharmacologic targetPolycystin-1Carboxyl-terminal fragmentKidney cystsPC1 expressionPotential causesDiseaseDistinct mutationsPost-translational modificationsMultiple complementary approachesGenes PKD1