2014
Mutation of Nogo-B Receptor, a Subunit of cis-Prenyltransferase, Causes a Congenital Disorder of Glycosylation
Park EJ, Grabińska K, Guan Z, Stránecký V, Hartmannová H, Hodaňová K, Barešová V, Sovová J, Jozsef L, Ondrušková N, Hansíková H, Honzík T, Zeman J, Hůlková H, Wen R, Kmoch S, Sessa WC. Mutation of Nogo-B Receptor, a Subunit of cis-Prenyltransferase, Causes a Congenital Disorder of Glycosylation. Cell Metabolism 2014, 20: 448-457. PMID: 25066056, PMCID: PMC4161961, DOI: 10.1016/j.cmet.2014.06.016.Peer-Reviewed Original ResearchConceptsProtein glycosylationCis-prenyltransferaseGPI anchor biosynthesisDolichol synthesisSynthesis of dolicholO-mannosylationAnchor biosynthesisFirst enzymeGenetic basisC-terminusCongenital disorderFunction mutationsGlycosylationEssential roleEnhanced accumulationMutationsYeastNgBRSubunitsDolicholFibroblastsBiosynthesisTerminusFree cholesterolProtein
2009
The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae
Kuranda K, Grabinska K, Berges T, Karst F, Leberre V, Sokol S, François J, Palamarczyk G. The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae. FEMS Yeast Research 2009, 9: 381-390. PMID: 19416104, DOI: 10.1111/j.1567-1364.2009.00485.x.Peer-Reviewed Original ResearchConceptsIsoprenoid pathwayFPP synthaseTwo-hybrid screenMembrane-associated proteinsBiosynthesis of hemeIsoprenoid biosynthesisProtein partnersPresence of lovastatinYeast SaccharomycesN-glycosylationSterol biosynthesisSqualene synthaseCis-prenyltransferaseEndoplasmic reticulumIsoprenoid compoundsZaragozic acidsBiosynthesisCellular levelGenesEnzymatic activityExpression levelsSaccharomycesPathwaySynthaseRegulation
2006
Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III Activity and Chitin Chain Length▿
Grabińska K, Magnelli P, Robbins P. Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III Activity and Chitin Chain Length▿. MSphere 2006, 6: 328-336. PMID: 17142567, PMCID: PMC1797950, DOI: 10.1128/ec.00203-06.Peer-Reviewed Original ResearchConceptsChitin synthase IIIChitin synthase III activityPlasma membrane associationC-terminal endMembrane associationCSIII activityChs4pCatalytic subunitProtein factorsChitin biosynthesisSynthase IIIFarnesyl transferaseYeast cellsPrenylationChitin polymersPrenyl moietyEnzymatic activityChitin contentAttachment sitesAverage chain lengthChs3pSaccharomycesVivoBiosynthesisFTase
2005
Functional relationships between the Saccharomyces cerevisiae cis-prenyltransferases required for dolichol biosynthesis.
Grabińska K, Sosińska G, Orłowski J, Swiezewska E, Berges T, Karst F, Palamarczyk G. Functional relationships between the Saccharomyces cerevisiae cis-prenyltransferases required for dolichol biosynthesis. Acta Biochimica Polonica 2005, 52: 221-32. PMID: 15827619, DOI: 10.18388/abp.2005_3511.Peer-Reviewed Original ResearchConceptsEnzymatic activityCis-prenyltransferase activityLong-chain dolicholsYeast SaccharomycesShorter speciesRER2Dolichol biosynthesisLevels of mRNADiphosphate formationIsoprene unitsSRT1SaccharomycesOverexpressionDolichol contentGenesPreferential synthesisProteinFunctional relationshipMRNADPM1TranscriptionBiosynthesisFarnesylSpecies
2002
Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase
Grabińska K, Palamarczyk G. Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. FEMS Yeast Research 2002, 2: 259-265. DOI: 10.1111/j.1567-1364.2002.tb00093.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDolichol biosynthesisMevalonate pathwayYeast Saccharomyces cerevisiaeTranscription of genesAAA ATPase familyNon-sterol derivativesEffects of overexpressionATPase familyNon-sterol compoundsProtein glycosylationSaccharomyces cerevisiaeFirst enzymeIsoprenoid lipidsRegulatory enzymeRegulatory roleEffects of FPPBiosynthesisFarnesylCoA reductaseMevalonic acidPathwayEnzymeSynthaseFPPPresent reviewDolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase
Grabińska K, Palamarczyk G. Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. FEMS Yeast Research 2002, 2: 259-265. PMID: 12702274, DOI: 10.1016/s1567-1356(02)00110-1.Peer-Reviewed Original ResearchConceptsFarnesyl diphosphateDolichol biosynthesisMevalonate pathwayOverexpression of farnesyl diphosphate synthaseYeast Saccharomyces cerevisiaeAAA ATPase familyFarnesyl diphosphate synthaseDerivatives of mevalonic acidDiphosphate synthaseProtein glycosylationATPase familyIsoprenoid lipidsRegulatory enzymeMevalonic acidMevalonateRegulatory roleBiosynthesisDolicholYeastPathwayProteinEnzymeYta7FarnesylationTranscriptionThe isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis
Kamińska J, Grabińska K, Kwapisz M, Sikora J, Smagowicz W, Palamarczyk G, Żołądek T, Boguta M. The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. FEMS Yeast Research 2002, 2: 31-37. DOI: 10.1016/s1567-1356(01)00059-9.Peer-Reviewed Original ResearchIsoprenoid pathwayIsoprenoid biosynthetic pathwayCellular tRNA levelsTRNA synthesisTRNA biosynthesisTRNA levelsSaccharomyces cerevisiaeBiosynthetic pathwayComplex regulationIsopentenyltransferaseProtein levelsMutantsErgosterol contentBiosynthesisPathwayIsopentenylationCerevisiaeSaccharomycesYeastTranscriptsRegulationExpressionDirect effectCellsThe isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis
Kamińska J, Grabińska K, Kwapisz M, Sikora J, Smagowicz W, Palamarczyk G, Żołądek T, Boguta M. The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. FEMS Yeast Research 2002, 2: 31-37. PMID: 12702319, DOI: 10.1111/j.1567-1364.2002.tb00066.x.Peer-Reviewed Original ResearchConceptsIsoprenoid pathwayIsoprenoid biosynthetic pathwayCellular tRNA levelsTRNA synthesisTRNA biosynthesisTRNA levelsSaccharomyces cerevisiaeBiosynthetic pathwayComplex regulationIsopentenyltransferaseProtein levelsMutantsErgosterol contentBiosynthesisPathwayIsopentenylationCerevisiaeSaccharomycesYeastTranscriptsRegulationExpressionDirect effectCells