Featured Publications
Unraveling Mechanisms Regulating Systemic Iron Homeostasis
Finberg KE. Unraveling Mechanisms Regulating Systemic Iron Homeostasis. Hematology 2011, 2011: 532-537. PMID: 22160085, PMCID: PMC3648641, DOI: 10.1182/asheducation-2011.1.532.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic iron homeostasisIron homeostasisProduction of hepcidinSystemic iron balanceHepcidin levelsRed blood cellsIron overloadDietary ironErythropoietic activityHepcidin responseAnimal modelsIron balanceIron disordersIron deficiencyBlood cellsHepcidinPhysiological stimuliDeleterious effectsLiverIron loadingHomeostasisTissue culture systemMolecular mechanismsKey regulatorAvailability of iron
2021
12 Iron Metabolism and Related Disorders
Ginzburg Y, Finberg K. 12 Iron Metabolism and Related Disorders. 2021, 445-499. DOI: 10.1016/b978-0-12-812535-9.00012-1.ChaptersGene productsNumerous fundamental biological processesFundamental biological processesIron metabolismGenetic defectsSystemic iron balanceSystemic iron regulationMolecular geneticsBiological processesIron regulationIron-refractory iron deficiency anemiaIron homeostasisIron availabilityFriedreich's ataxiaIron movementMajor genetic disordersErythroid precursorsGenetic disordersIron regulatory hormone hepcidinSideroblastic anemiaMetabolismGenetic formsMutationsKey roleHormone hepcidin
2013
Regulation of systemic iron homeostasis
Finberg KE. Regulation of systemic iron homeostasis. Current Opinion In Hematology 2013, 20: 208-214. PMID: 23426198, DOI: 10.1097/moh.0b013e32835f5a47.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSystemic iron balanceMolecular mechanismsBone morphogenetic protein (BMP) type IHypoxia-inducible factor (HIF) pathwayInducible factor pathwayProtein type IHepcidin synthesisIron balanceBMP pathwayTransferrin receptor 2Systemic iron homeostasisCapacity of erythropoietinIron homeostasisComplex biologyNonredundant roleTissue culture systemHepcidin levelsInfectious stimuliIron storesFactor pathwayDietary ironErythropoietic activityReceptor 2PathwayAnimal models