2015
Biochemical and Functional Characterization of the Mutagenic Cytidine Deaminase, APOBEC3B
Sasaki T, Anderson K. Biochemical and Functional Characterization of the Mutagenic Cytidine Deaminase, APOBEC3B. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.573.48.Peer-Reviewed Original ResearchBiochemical experimentsMolecular mechanismsCytidine deaminaseFamily proteinsRNA editingBind DNANon-small cell lung cancerFunctional characterizationCellular cytidine deaminasesDiverse rolesEnzymatic capacityPhysiological processesPolypeptide 3APOBEC3BProteinProtein levelsSquamous cell lung carcinomaDeaminaseCatalytic polypeptide 3Cell lung carcinomaCell lung cancerCarcinogenesisTargeted treatment strategiesLung carcinomaTargeted therapy
2007
Epidermal Growth Factor Receptor Mutants from Human Lung Cancers Exhibit Enhanced Catalytic Activity and Increased Sensitivity to Gefitinib
Mulloy R, Ferrand A, Kim Y, Sordella R, Bell D, Haber D, Anderson K, Settleman J. Epidermal Growth Factor Receptor Mutants from Human Lung Cancers Exhibit Enhanced Catalytic Activity and Increased Sensitivity to Gefitinib. Cancer Research 2007, 67: 2325-2330. PMID: 17332364, DOI: 10.1158/0008-5472.can-06-4293.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorEpidermal growth factor receptor mutantMultiple levels in vivoIn vitro kinase assayEpidermal growth factor receptor functionPurified recombinant proteinWild-type epidermal growth factor receptorSensitivity to kinase inhibitionNon-small cell lung cancerCOOH-terminal tyrosineHuman non-small cell lung cancerIncreased sensitivity to gefitinibSensitivity to gefitinibCell lung cancerAutophosphorylation activityGrowth factor receptorCell-based studiesEGFR kinase inhibitorsCytoplasmic domainRecombinant proteinsKinase assayEnzyme functionDownstream effectorsMutantsKinase activity