2012
Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia
Jiang X, Huang H, Li Z, Li Y, Wang X, Gurbuxani S, Chen P, He C, You D, Zhang S, Wang J, Arnovitz S, Elkahloun A, Price C, Hong GM, Ren H, Kunjamma RB, Neilly MB, Matthews JM, Xu M, Larson RA, Le Beau MM, Slany RK, Liu PP, Lu J, Zhang J, He C, Chen J. Blockade of miR-150 Maturation by MLL-Fusion/MYC/LIN-28 Is Required for MLL-Associated Leukemia. Cancer Cell 2012, 22: 524-535. PMID: 23079661, PMCID: PMC3480215, DOI: 10.1016/j.ccr.2012.08.028.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCell Transformation, NeoplasticDNA MethylationDown-RegulationFms-Like Tyrosine Kinase 3Gene DosageGene Expression Regulation, LeukemicHistone-Lysine N-MethyltransferaseHomeodomain ProteinsHumansLeukemiaMiceMicroRNAsMutationMyeloid Ecotropic Viral Integration Site 1 ProteinMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsNuclear ProteinsProto-Oncogene Proteins c-mycRNA-Binding ProteinsSignal TransductionConceptsMiR-150MiR-150 functionsLeukemic cell growthPathogenesis of leukemiaHoxa9/Meis1Acute leukemiaDysregulation of miRNAsExpression of microRNAsPivotal gatekeeperLeukemiaFunctional axisCell growthLeukemogenesisMYC/MLL fusion proteinsBlockadePathogenesisPosttranscriptional levelExpressionFusion proteinFLT3
2007
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19971-19976. PMID: 18056805, PMCID: PMC2148407, DOI: 10.1073/pnas.0709313104.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaAcute leukemiaMyeloid leukemiaExpression signaturesCommon acute leukemiaCommon childhood cancerCommon cytogenetic subtypeMicroRNA expression signatureNormal control samplesAcute leukemia samplesBetter prognosisChildhood cancerReal-time PCRCytogenetic subtypesMiR-223LeukemiaMiR-128aLeukemia samplesPromoter hypomethylationMiR-128MicroRNA expressionDiagnosisRegulation of expressionMicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia.
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly M, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander S, Le M, Larson R, Golub T, Rowley J, Chen J. MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia. Blood 2007, 110: 231. DOI: 10.1182/blood.v110.11.231.231.Peer-Reviewed Original ResearchAcute myeloid leukemiaAcute lymphoblastic leukemiaAcute leukemiaLymphoblastic leukemiaMyeloid leukemiaMiR-128aOverall survival rateExpression signaturesCommon cytogenetic subtypeMicroRNA expression signatureAcute leukemia samplesDevelopment of cancerFlow cytometric methodHuman acute leukemiaQuantitative real-time PCRReal-time PCRT cellsCytogenetic subtypesNormal controlsSurvival rateMiR-223Vivo modelLeukemiaNovel markerTarget genes