2018
Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network
Deng Y, Pakdel M, Blank B, Sundberg EL, Burd CG, von Blume J. Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network. Developmental Cell 2018, 47: 464-478.e8. PMID: 30393074, PMCID: PMC6261503, DOI: 10.1016/j.devcel.2018.10.012.Peer-Reviewed Original ResearchMeSH KeywordsCalciumCalcium-Transporting ATPasesCell MembraneHeLa CellsHumansIntracellular MembranesProtein TransportSecretory PathwaySphingomyelinsTrans-Golgi NetworkConceptsTrans-Golgi networkTGN membranesCell surface transportProtein sortingTrafficking pathwaysSecretion pathwaySecretory proteinsSphingomyelin synthesisSorting mechanismLipid synthesisProteinVesicular carriersCab45Sphingomyelin contentNew lipidSortingPrincipal functionMembranePathwayCore componentLipidsGolgiSurface transportExportActivityExploring new routes for secretory protein export from the trans-Golgi network
Pakdel M, von Blume J. Exploring new routes for secretory protein export from the trans-Golgi network. Molecular Biology Of The Cell 2018, 29: 235-240. PMID: 29382805, PMCID: PMC5996961, DOI: 10.1091/mbc.e17-02-0117.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonCalciumCalcium-Binding ProteinsCalcium-Transporting ATPasesHeLa CellsHomeostasisHumansHydrolasesLysosomesProtein TransportSecretory PathwayTrans-Golgi NetworkConceptsSecretory cargoSecretory proteinsCytoplasmic actin cytoskeletonMajor sorting stationTrans-Golgi networkGolgi residentsProtein exportGolgi networkActin cytoskeletonATPase SPCA1Cellular compartmentsTissue homeostasisSorting stationSoluble proteinTGNLysosomal hydrolasesOverall pathwayLuminal CaRecent discoveryProteinCargoSpecific carrierSortingCellsFinal destination
2015
Julia von Blume: Sorting through the trans-Golgi
von Blume J, Sedwick C. Julia von Blume: Sorting through the trans-Golgi. Journal Of Cell Biology 2015, 208: 4-5. PMID: 25559180, PMCID: PMC4284231, DOI: 10.1083/jcb.2081pi.Peer-Reviewed Original Research
2014
Cofilin recruits F-actin to SPCA1 and promotes Ca2+-mediated secretory cargo sorting
Kienzle C, Basnet N, Crevenna AH, Beck G, Habermann B, Mizuno N, von Blume J. Cofilin recruits F-actin to SPCA1 and promotes Ca2+-mediated secretory cargo sorting. Journal Of Cell Biology 2014, 206: 635-654. PMID: 25179631, PMCID: PMC4151145, DOI: 10.1083/jcb.201311052.Peer-Reviewed Original ResearchMeSH KeywordsActinsCalciumCalcium SignalingCalcium-Transporting ATPasesCofilin 1HeLa CellsHumansPoint MutationProtein BindingProtein Interaction Domains and MotifsProtein TransportSecretory Pathway
2011
ADF/Cofilin Regulates Secretory Cargo Sorting at the TGN via the Ca2+ ATPase SPCA1
von Blume J, Alleaume AM, Cantero-Recasens G, Curwin A, Carreras-Sureda A, Zimmermann T, van Galen J, Wakana Y, Valverde MA, Malhotra V. ADF/Cofilin Regulates Secretory Cargo Sorting at the TGN via the Ca2+ ATPase SPCA1. Developmental Cell 2011, 20: 652-662. PMID: 21571222, DOI: 10.1016/j.devcel.2011.03.014.Peer-Reviewed Original ResearchMeSH KeywordsActin Depolymerizing FactorsCalciumCalcium-Transporting ATPasesCells, CulturedDestrinEndoplasmic ReticulumHeLa CellsHumansTrans-Golgi Network