2019
Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature 2019, 569: 236-240. PMID: 31043745, PMCID: PMC6716525, DOI: 10.1038/s41586-019-1167-6.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsChronic inflammationDestabilization of plaquesGlobal medical burdenImportant pathophysiological contributorCell deathPerpetuation of inflammationChronic vascular diseaseNeutrophil extracellular trapsMajor underlying causeLytic cell deathPathophysiological contributorVascular diseaseMedical burdenExtracellular trapsMouse modelAtherosclerotic lesionsMolecular mediatorsInflammationTissue damageTherapeutic valueMuscle cellsUnderlying causeDeathHistone H4
2015
Julia von Blume: Sorting through the trans-Golgi
von Blume J, Sedwick C. Julia von Blume: Sorting through the trans-Golgi. Journal Of Cell Biology 2015, 208: 4-5. PMID: 25559180, PMCID: PMC4284231, DOI: 10.1083/jcb.2081pi.Peer-Reviewed Original Research
2014
Cofilin recruits F-actin to SPCA1 and promotes Ca2+-mediated secretory cargo sorting
Kienzle C, Basnet N, Crevenna AH, Beck G, Habermann B, Mizuno N, von Blume J. Cofilin recruits F-actin to SPCA1 and promotes Ca2+-mediated secretory cargo sorting. Journal Of Cell Biology 2014, 206: 635-654. PMID: 25179631, PMCID: PMC4151145, DOI: 10.1083/jcb.201311052.Peer-Reviewed Original Research
2012
Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network
von Blume J, Alleaume AM, Kienzle C, Carreras-Sureda A, Valverde M, Malhotra V. Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network. Journal Of Cell Biology 2012, 199: 1057-1066. PMID: 23266954, PMCID: PMC3529532, DOI: 10.1083/jcb.201207180.Peer-Reviewed Original ResearchMeSH KeywordsCalciumCalcium SignalingCalcium-Binding ProteinsCartilage Oligomeric Matrix ProteinCathepsin DExtracellular Matrix ProteinsGene Knockdown TechniquesGlycoproteinsHeLa CellsHomeostasisHumansMatrilin ProteinsProtein BindingProtein IsoformsProtein TransportRNA InterferenceSecretory PathwayTrans-Golgi Network