Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction*
Gendron JM, Webb K, Yang B, Rising L, Zuzow N, Bennett EJ. Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction*. Molecular & Cellular Proteomics 2016, 15: 2576-2593. PMID: 27185884, PMCID: PMC4974337, DOI: 10.1074/mcp.m116.058420.Peer-Reviewed Original ResearchConceptsUbiquitylation eventsProtein homeostasisProtein populationHomeostasis dysfunctionGlobal protein homeostasisP97/VCPDistinct protein populationsQuantitative proteomics methodHomeostasis functionsUbiquitin-proteasome systemDistinct functional outcomesProteomic methodsProteasome systemSubcellular fractionationProteomeFluorescent reportersHuman pathologiesProteasome dysfunctionDistinct insultsUbReporterPotent inhibitorHomeostasisUnique alterationsKey role