2001
Ratio of nuchal thickness to humerus length for Down syndrome detection
Bahado-Singh R, Oz U, Hsu C, Deren O, Copel J, Mahoney M. Ratio of nuchal thickness to humerus length for Down syndrome detection. American Journal Of Obstetrics And Gynecology 2001, 184: 1284-1288. PMID: 11349203, DOI: 10.1067/mob.2001.113878.Peer-Reviewed Original ResearchConceptsDown syndrome riskHigh-risk groupMaternal ageSyndrome riskNuchal thicknessDown syndromeDown syndrome detectionStudy populationIndividual Down's syndrome riskMean gestational ageOverall study populationAge-related riskHumerus lengthSyndrome detectionDown syndrome casesDown's syndrome likelihood ratiosGestational ageProspective dataHealthy groupGross anomaliesNormal fetusesSyndrome casesBiparietal diameterAmniocentesis casesFetal population
1999
A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age
Bahado-Singh R, Oz U, Kovanci E, Cermik D, Copel J, Mahoney M, Cole L. A high-sensitivity alternative to “routine” genetic amniocentesis: Multiple urinary analytes, nuchal thickness, and age. American Journal Of Obstetrics And Gynecology 1999, 180: 169-173. PMID: 9914599, DOI: 10.1016/s0002-9378(99)70170-5.Peer-Reviewed Original ResearchConceptsAdvanced maternal ageNuchal thicknessMaternal ageGenetic amniocentesisDown syndrome detection rateUrinary beta-core fragmentUrinary analytesMaternal age-related riskRisk thresholdSyndrome detection rateTotal study populationHigh-risk groupAge-related riskBeta-core fragmentRate of amniocentesisHuman chorionic gonadotropinDown syndrome riskDown's syndrome likelihood ratiosDown's syndrome screening efficiencyLikelihood ratioCommon indicationFalse positive rateNormal medianPregnant womenSyndrome risk
1998
An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers
Bahado-Singh R, Deren O, Oz U, Tan A, Hunter D, Copel J, Mahoney M. An alternative for women initially declining genetic amniocentesis: Individual Down syndrome odds on the basis of maternal age and multiple ultrasonographic markers. American Journal Of Obstetrics And Gynecology 1998, 179: 514-519. PMID: 9731862, DOI: 10.1016/s0002-9378(98)70388-6.Peer-Reviewed Original ResearchConceptsHyperechoic fetal bowelMaternal ageDown syndromeFetal bowelUltrasonographic parametersScreen-positive rateSignificant independent predictorsAge-related riskDown syndrome riskIndividual oddsLikelihood ratioPositive predictive valueHypoplastic fifth digitDigit hypoplasiaWeeks' gestationIndependent predictorsNormal medianIndividual Down syndrome oddsSingleton fetusesSyndrome riskUltrasonographic markersSerum screeningGenetic amniocentesisHigh riskNuchal thickening