2018
Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals
Böhme U, Otto TD, Cotton JA, Steinbiss S, Sanders M, Oyola SO, Nicot A, Gandon S, Patra KP, Herd C, Bushell E, Modrzynska KK, Billker O, Vinetz JM, Rivero A, Newbold CI, Berriman M. Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals. Genome Research 2018, 28: 547-560. PMID: 29500236, PMCID: PMC5880244, DOI: 10.1101/gr.218123.116.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBirdsEvolution, MolecularHumansMalaria, AvianMammalsPhylogenyPlasmodiumPlasmodium falciparumPlasmodium vivaxConceptsAvian malaria speciesLTR retrotransposonsHigh-quality draft genome sequenceClades of parasitesComplete LTR retrotransposonsLineage-specific evolutionNovel gene familyOrthologs of genesMalaria parasite genomeAvian malaria parasitesAmino acid divergenceDraft genome sequenceInvasion-related genesAvian lineagesMalaria speciesProtein homologsGene familyMultigene familyPhylogenetic positionTransposable elementsBird speciesParasite genomePhylogenetic analysisGenome sequenceAvian malaria
2016
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLOS Neglected Tropical Diseases 2016, 10: e0004403. PMID: 26890609, PMCID: PMC4758666, DOI: 10.1371/journal.pntd.0004403.Peer-Reviewed Original ResearchConceptsGenes/gene familiesProtein secretion systemComparative genomic analysisSignal peptide motifsCRISPR/Cas systemComputational biology analysisMammalian host adaptationBacterial pathogensWhole-genome analysisSialic acid biosynthesisLeptospira speciesEvolutionary relatednessSaprophytic Leptospira speciesGene familyMetabolic reconstructionGenomic comparisonSecretion motifBacterial virulence factorsHost adaptationSecretion systemGenome analysisAcid biosynthesisGenomic analysisNew insightsMammalian hosts