2001
Knockout of the Rodent Malaria Parasite Chitinase PbCHT1 Reduces Infectivity to Mosquitoes
Dessens J, Mendoza J, Claudianos C, Vinetz J, Khater E, Hassard S, Ranawaka G, Sinden R. Knockout of the Rodent Malaria Parasite Chitinase PbCHT1 Reduces Infectivity to Mosquitoes. Infection And Immunity 2001, 69: 4041-4047. PMID: 11349074, PMCID: PMC98467, DOI: 10.1128/iai.69.6.4041-4047.2001.Peer-Reviewed Original ResearchConceptsPeritrophic matrixChitinase geneChitinase activityHuman malaria parasite Plasmodium falciparumMalaria parasite Plasmodium falciparumPlasmodium-mosquito interactionsAvian malaria parasite Plasmodium gallinaceumAvian malaria transmissionParasite Plasmodium falciparumMalaria parasite Plasmodium gallinaceumChitin-containing structuresNull mutantsRodent malaria parasiteInfected blood mealMalaria ookinetesTransmission-blocking drugsAnopheles stephensi mosquitoesMidgut invasionStructural orthologsMosquito midgutOokinete invasionPM disruptionMidgut epitheliumTargeted disruptionMalaria transmission
1999
Chitinases of human parasites and their implications as antiparasitic targets.
Shahabuddin M, Vinetz J. Chitinases of human parasites and their implications as antiparasitic targets. EXS 1999, 87: 223-34. PMID: 10906963, DOI: 10.1007/978-3-0348-8757-1_16.Peer-Reviewed Original ResearchConceptsDevelopmental stage-specific mannerStage-specific mannerAmino acid sequenceChitin-containing structuresPathogenic parasitesAnimal diseasesAntiparasitic targetsChitinase geneInsect vectorsAcid sequenceSuccessful infectionChitinasesHuman parasitesParasitesNumber of humanGenesLife cycleChitinAnimal bodyPathogensRecent studiesHarsh conditionsVertebratesChitinaseOrganisms