2022
The prevalence of mental health disorders in people with HIV and the effects on the HIV care continuum
Lang R, Hogan B, Zhu J, McArthur K, Lee J, Zandi P, Nestadt P, Silverberg M, Parcesepe A, Cook J, Gill M, Grelotti D, Closson K, Lima V, Goulet J, Horberg M, Gebo K, Camoens R, Rebeiro P, Nijhawan A, McGinnis K, Eron J, Althoff K. The prevalence of mental health disorders in people with HIV and the effects on the HIV care continuum. AIDS 2022, 37: 259-269. PMID: 36541638, PMCID: PMC9782734, DOI: 10.1097/qad.0000000000003420.Peer-Reviewed Original ResearchMeSH KeywordsAnxiety DisordersContinuity of Patient CareHIV InfectionsHumansMental DisordersMental HealthPrevalenceConceptsMental health disordersMore mental health disordersAdjusted prevalence ratiosViral suppressionBipolar disorderHealth disordersNorth American AIDS Cohort CollaborationPrevalence of MHDsHIV care continuum outcomesAnxiety disordersCare continuum outcomesMental health multimorbidityHIV care continuumPrevalence of depressiveCohort CollaborationContinuum outcomesPrevalence ratiosDepressive disorderCare continuumObservational studyLow prevalenceInternational ClassificationMultimorbidityPWHPrevalenceA Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996–2020)
Smith A, Breazeale S, Goulet JL, Vlahov D, Justice AC, Womack JA. A Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996–2020). AIDS And Behavior 2022, 26: 2559-2573. PMID: 35107660, DOI: 10.1007/s10461-022-03591-y.Peer-Reviewed Original ResearchConceptsRisk factorsHIV-specific risk factorsInjection drug useHIV-1 RNACause of morbidityShare risk factorsPrevious suicide attemptsQuantitative study designHIV diagnosisPeer-reviewed journalsHIV infectionEligible studiesInclusion criteriaPsychiatric illnessElevated riskGeneral populationAlcohol misuseElectronic databasesDrug useSystematic reviewSuicide attemptsStudy designInitial searchSearch termsHIV
2020
Are we missing opioid-related deaths among people with HIV?
Becker WC, Gordon KS, Edelman EJ, Goulet JL, Kerns RD, Marshall BDL, Fiellin DA, Justice AC, Tate JP. Are we missing opioid-related deaths among people with HIV? Drug And Alcohol Dependence 2020, 212: 108003. PMID: 32417360, PMCID: PMC9580216, DOI: 10.1016/j.drugalcdep.2020.108003.Peer-Reviewed Original ResearchConceptsVeterans Aging Cohort StudyOpioid useOverdose deathsLife-limiting conditionsUnnatural deathsGreater oddsAging Cohort StudyVACS IndexOpioid exposureCohort studyHIV infectionHIV statusRisk factorsOdds ratioDeath filesIndex causeHIVDisease severityDeathDecedentsIllicit useDifferential misclassificationOddsCauseOpioids
2019
Predictors of initiation of and retention on medications for alcohol use disorder among people living with and without HIV
Oldfield BJ, McGinnis KA, Edelman EJ, Williams EC, Gordon AJ, Akgün K, Crystal S, Fiellin LE, Gaither JR, Goulet JL, Korthuis PT, Marshall BDL, Justice AC, Bryant K, Fiellin DA, Kraemer KL. Predictors of initiation of and retention on medications for alcohol use disorder among people living with and without HIV. Journal Of Substance Use And Addiction Treatment 2019, 109: 14-22. PMID: 31856946, PMCID: PMC6982467, DOI: 10.1016/j.jsat.2019.11.002.Peer-Reviewed Original ResearchMeSH KeywordsAcamprosateAlcohol DeterrentsAlcoholismCohort StudiesFemaleHIV InfectionsHumansMaleMiddle AgedNaltrexonePrevalenceVeteransConceptsAlcohol use disorderUse disordersHIV statusUninfected individualsVeterans Aging Cohort Study (VACS) dataEvidence-based medicationsNew alcohol use disorderPrevalence of initiationMultivariable logistic regressionPredictors of initiationFacility-level predictorsCohort study dataMedication initiationPrescription fillsMultivariable analysisBlack raceTreatment gapDecreased oddsNew diagnosisPLWHOlder ageLogistic regressionMedicationsHIVSpecific subpopulationsScreening for Military Sexual Trauma Is Associated With Improved HIV Screening in Women Veterans
Reddy SM, Portnoy GA, Bathulapalli H, Womack J, Haskell SG, Mattocks K, Brandt CA, Goulet JL. Screening for Military Sexual Trauma Is Associated With Improved HIV Screening in Women Veterans. Medical Care 2019, 57: 536-543. PMID: 31194701, DOI: 10.1097/mlr.0000000000001130.Peer-Reviewed Original ResearchConceptsMilitary sexual traumaWomen veteransCohort studyComprehensive preventive health careVeterans AffairsSexual traumaOdds of HIVPositive MST screenHIV risk factorsWomen Veterans Cohort StudyHealth careCross-sectional studyMental health diagnosesPreventive health careFacility-level clusteringHistory of MSTMST screenHIV screeningMultivariable analysisHIV screenRisk factorsHIVHealth diagnosisBivariate statisticsDemographic characteristicsDepression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study
So‐Armah K, Gupta S, Kundu S, Stewart J, Goulet J, Butt A, Sico J, Marconi, Crystal S, Rodriguez‐Barradas M, Budoff M, Gibert C, Chang C, Bedimo R, Freiberg. Depression and all‐cause mortality risk in HIV‐infected and HIV‐uninfected US veterans: a cohort study. HIV Medicine 2019, 20: 317-329. PMID: 30924577, PMCID: PMC6459698, DOI: 10.1111/hiv.12726.Peer-Reviewed Original ResearchConceptsHIV infectionMajor depressive disorderHIV statusDepressive symptomsMedian followCause mortalityDepressive disorderMortality riskVeterans Aging Cohort Study (VACS) dataDeath rateMajor depressive disorder diagnosisFirst clinic visitCause mortality riskPHQ-9 scoresNinth Revision codesPatient Health QuestionnaireDepressive disorder diagnosisPHQ-9 dataCohort study dataContribution of depressionDepression definitionsClinic visitsCohort studyComorbid conditionsEligible participants
2018
Patterns of Alcohol Use Among Patients Living With HIV in Urban, Large Rural, and Small Rural Areas
Bensley KM, McGinnis KA, Fortney J, Chan KCG, Dombrowski JC, Ornelas I, Edelman EJ, Goulet JL, Satre DD, Justice AC, Fiellin DA, Williams EC. Patterns of Alcohol Use Among Patients Living With HIV in Urban, Large Rural, and Small Rural Areas. The Journal Of Rural Health 2018, 35: 330-340. PMID: 30339740, PMCID: PMC6502702, DOI: 10.1111/jrh.12326.Peer-Reviewed Original ResearchConceptsSmall rural areasAlcohol useAUDIT-C alcoholElectronic health record dataHealth record dataAlcohol-related interventionsPrevalence of AUDAlcohol use outcomesHeavy episodic drinkingPLWHRural areasReporting useHIVUse outcomesRecord dataEpisodic drinkingPatientsPrevalenceRegression modelsDrinkingRuralityAUDUnique challenges
2016
Minority Men Who Have Sex with Men Demonstrate Increased Risk for HIV Transmission
Gordon KS, Edelman EJ, Justice AC, Fiellin DA, Akgün K, Crystal S, Duggal M, Goulet JL, Rimland D, Bryant KJ. Minority Men Who Have Sex with Men Demonstrate Increased Risk for HIV Transmission. AIDS And Behavior 2016, 21: 1497-1510. PMID: 27771818, PMCID: PMC5380471, DOI: 10.1007/s10461-016-1590-8.Peer-Reviewed Original ResearchConceptsDetectable HIV-1 RNAHIV-1 RNAHIV transmissionOdds ratioMSM groupVeterans Aging Cohort StudyMinority MSMAging Cohort StudyMultiple sexual partnersMultiple sex partnersNon-condom useCohort studyInfluence of drugsComparator groupRisk factorsHispanic MSMWhite MSMLow prevalenceHigh incidenceSex partnersSexual partnersMSMSexMinority menGroupHepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection
Tetrault JM, Tate JP, Edelman EJ, Gordon AJ, Re V, Lim JK, Rimland D, Goulet J, Crystal S, Gaither JR, Gibert CL, Rodriguez-Barradas MC, Fiellin LE, Bryant K, Justice AC, Fiellin DA. Hepatic Safety of Buprenorphine in HIV-Infected and Uninfected Patients With Opioid Use Disorder: The Role of HCV-Infection. Journal Of Substance Use And Addiction Treatment 2016, 68: 62-67. PMID: 27431048, PMCID: PMC4976086, DOI: 10.1016/j.jsat.2016.06.002.Peer-Reviewed Original ResearchConceptsLiver enzyme elevationAlcohol use disorderUninfected patientsHepatotoxic medicationsHCV infectionUse disordersComposite endpointLiver injuryHIV/HCV co-infected patientsHCV co-infected patientsHIV/HCV statusPre-existing liver injuryCo-infected patientsCohort of HIVHepatitis C infectionHIV/HCVOpioid use disorderRisk of hepatotoxicityHCV statusHepatic safetyMedian ALTC infectionChart reviewEnzyme elevationHIV infectionContemplation of Smoking Cessation and Quit Attempts in Human Immunodeficiency Virus–Infected and Uninfected Veterans
Shahrir S, Tindle HA, McGinnis KA, Fiellin DA, Goulet J, Akgün KM, Gibert CL, Rodriguez-Barradas MC, Crothers K. Contemplation of Smoking Cessation and Quit Attempts in Human Immunodeficiency Virus–Infected and Uninfected Veterans. Substance Use & Addiction Journal 2016, 37: 315-322. PMID: 26167725, DOI: 10.1080/08897077.2015.1062458.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useVeterans Aging Cohort StudyHuman immunodeficiency virusSmoking cessationQuit attemptsPulmonary disease diagnosisPrior quit attemptsAlcohol useImmunodeficiency virusKey modifiable risk factorsStratified multivariable analysesSustained smoking cessationModifiable risk factorsAging Cohort StudyStudy of HIVUninfected smokersUninfected veteransUninfected patientsCohort studyCessation ratesHIV statusMultivariable analysisRisk factorsOdds ratioTargeting HIVThe Association Between Receipt of Guideline-Concordant Long-Term Opioid Therapy and All-Cause Mortality
Gaither JR, Goulet JL, Becker WC, Crystal S, Edelman EJ, Gordon K, Kerns RD, Rimland D, Skanderson M, Justice AC, Fiellin DA. The Association Between Receipt of Guideline-Concordant Long-Term Opioid Therapy and All-Cause Mortality. Journal Of General Internal Medicine 2016, 31: 492-501. PMID: 26847447, PMCID: PMC4835362, DOI: 10.1007/s11606-015-3571-4.Peer-Reviewed Original ResearchConceptsSubstance use disordersGuideline-concordant careCause mortalityOpioid therapyLong-term opioid therapyUntreated substance use disordersCurrent substance use disorderTerm opioid therapyTime-updated covariatesPrimary care visitsImportant clinical outcomesMulti-modal treatmentUrine drug testingUninfected patientsUntreated patientsCare visitsChronic painClinical outcomesCox regressionDecreased riskHigh comorbidityMortality burdenRehabilitative therapySUD treatmentHigh risk
2015
Trends in Any and High-Dose Opioid Analgesic Receipt Among Aging Patients With and Without HIV
Becker WC, Gordon K, Jennifer Edelman E, Kerns RD, Crystal S, Dziura JD, Fiellin LE, Gordon AJ, Goulet JL, Justice AC, Fiellin DA. Trends in Any and High-Dose Opioid Analgesic Receipt Among Aging Patients With and Without HIV. AIDS And Behavior 2015, 20: 679-686. PMID: 26384973, PMCID: PMC5006945, DOI: 10.1007/s10461-015-1197-5.Peer-Reviewed Original ResearchLong-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients
Weisberg DF, Gordon KS, Barry DT, Becker WC, Crystal S, Edelman EJ, Gaither J, Gordon AJ, Goulet J, Kerns RD, Moore BA, Tate J, Justice AC, Fiellin DA. Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 223-233. PMID: 26009831, PMCID: PMC4446730, DOI: 10.1097/qai.0000000000000591.Peer-Reviewed Original ResearchConceptsLong-term opioidsMorphine equivalent daily doseOpioid receiptRisk of deathLong-term prescriptionUninfected patientsOpioid dosesAntiretroviral therapyHazard ratioDaily dosePropensity scoreHigher opioid dosesCause mortalityHIV statusAvailable patientsMortality riskOpioidsHIVPatientsProspective analysisMortalityBenzodiazepinesDosesDeathRisk
2014
STI Diagnosis and HIV Testing Among OEF/OIF/OND Veterans
Goulet JL, Martinello RA, Bathulapalli H, Higgins D, Driscoll MA, Brandt CA, Womack JA. STI Diagnosis and HIV Testing Among OEF/OIF/OND Veterans. Medical Care 2014, 52: 1064-1067. PMID: 25334054, PMCID: PMC4232995, DOI: 10.1097/mlr.0000000000000253.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusHIV testing ratesSTI diagnosisHIV testingTesting ratesPatient characteristicsHigher HIV testing ratesPrevious HIV test resultsVeterans Health Administration (VHA) servicesRoutine HIV testingVHA administrative dataHIV test resultsRelative risk regressionSubstance abuse disordersPositive test resultsOEF/OIF/OND veteransPosttraumatic stress disorderHIV testImmunodeficiency virusRisk regressionInfection diagnosisMAIN OUTCOMEAbuse disordersService veteransOlder ageGuideline-Concordant Management of Opioid Therapy Among Human Immunodeficiency Virus (HIV)-Infected and Uninfected Veterans
Gaither JR, Goulet JL, Becker WC, Crystal S, Edelman EJ, Gordon K, Kerns RD, Rimland D, Skanderson M, Weisberg DF, Justice AC, Fiellin DA. Guideline-Concordant Management of Opioid Therapy Among Human Immunodeficiency Virus (HIV)-Infected and Uninfected Veterans. Journal Of Pain 2014, 15: 1130-1140. PMID: 25152300, PMCID: PMC4253900, DOI: 10.1016/j.jpain.2014.08.004.Peer-Reviewed Original ResearchConceptsCurrent substance use disorderGuideline-concordant careOpioid therapyUrine drug testsHuman immunodeficiency virusSubstance use disordersUninfected patientsImmunodeficiency virusUse disordersPatient/provider characteristicsPrimary care provider visitsVeterans Affairs/DepartmentGuideline-concordant managementDrug testsCare concordantGuideline concordanceUninfected veteransProvider visitsPatient characteristicsPatient groupPrimary careClinical guidelinesPain medicineProvider characteristicsPatientsThe VACS Index Accurately Predicts Mortality and Treatment Response among Multi-Drug Resistant HIV Infected Patients Participating in the Options in Management with Antiretrovirals (OPTIMA) Study
Brown ST, Tate JP, Kyriakides TC, Kirkwood KA, Holodniy M, Goulet JL, Angus BJ, Cameron DW, Justice AC, . The VACS Index Accurately Predicts Mortality and Treatment Response among Multi-Drug Resistant HIV Infected Patients Participating in the Options in Management with Antiretrovirals (OPTIMA) Study. PLOS ONE 2014, 9: e92606. PMID: 24667813, PMCID: PMC3965438, DOI: 10.1371/journal.pone.0092606.Peer-Reviewed Original ResearchConceptsVACS IndexCombination antiretroviral therapyNet reclassification improvementHIV biomarkersCause mortalityC-statisticTreatment interventionsMulti-drug resistant HIVHarrel's c-statisticsRespective hazard ratiosKaplan-Meier estimatesProportional hazards modelImproved scoresAntiretroviral studiesAntiretroviral therapyHazard ratioResistant HIVReclassification improvementRestricted IndexTreatment responseStudy interventionRisk scoreHazards modelVAC indexMortalityRelationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients
Lim JK, Tate JP, Fultz SL, Goulet JL, Conigliaro J, Bryant KJ, Gordon AJ, Gibert C, Rimland D, Goetz MB, Klein MB, Fiellin DA, Justice AC, Re V. Relationship Between Alcohol Use Categories and Noninvasive Markers of Advanced Hepatic Fibrosis in HIV-Infected, Chronic Hepatitis C Virus–Infected, and Uninfected Patients. Clinical Infectious Diseases 2014, 58: 1449-1458. PMID: 24569533, PMCID: PMC4001286, DOI: 10.1093/cid/ciu097.Peer-Reviewed Original ResearchConceptsChronic hepatitis C virusAdvanced hepatic fibrosisHuman immunodeficiency virusHepatitis C virusAlcohol use categoriesAlcohol-related diagnosesHIV/HCV-coinfected patientsHepatic fibrosisAlcohol consumptionNonhazardous drinkingBinge drinkingHIV/HCV groupAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaireVeterans Aging Cohort StudyFIB-4 indexAging Cohort StudyCross-sectional studyHCV groupHCV statusHIV-InfectedUninfected participantsChronic hepatitisUninfected patientsCohort studyLiver disease
2013
Agreement Between Electronic Medical Record-based and Self-administered Pain Numeric Rating Scale
Goulet JL, Brandt C, Crystal S, Fiellin DA, Gibert C, Gordon AJ, Kerns RD, Maisto S, Justice AC. Agreement Between Electronic Medical Record-based and Self-administered Pain Numeric Rating Scale. Medical Care 2013, 51: 245-250. PMID: 23222528, PMCID: PMC3572341, DOI: 10.1097/mlr.0b013e318277f1ad.Peer-Reviewed Original ResearchConceptsNumeric rating scaleElectronic medical recordsPain screeningMedical recordsPain numeric rating scaleRating ScaleModerate-severe painVeterans Affairs medical facilitiesPatients' electronic medical recordsMajor depressive disorderEMR dataQuality of careUnderestimation of painSample of veteransPosttraumatic stress disorderHealth care systemClinical characteristicsPatient characteristicsNRS scoresPain careDepressive disorderSurvey scoresPainLevel of agreementStress disorderPhysiologic Frailty and Fragility Fracture in HIV-Infected Male Veterans
Womack JA, Goulet JL, Gibert C, Brandt CA, Skanderson M, Gulanski B, Rimland D, Rodriguez-Barradas MC, Tate J, Yin MT, Justice AC, Team F. Physiologic Frailty and Fragility Fracture in HIV-Infected Male Veterans. Clinical Infectious Diseases 2013, 56: 1498-1504. PMID: 23378285, PMCID: PMC3634308, DOI: 10.1093/cid/cit056.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusVACS Index scoreFragility fracturesPhysiologic frailtyVACS IndexMale veteransInhibitor useFracture riskRisk factorsVeterans Aging Cohort Study (VACS) IndexIndex scoreFragility fracture risk factorsICD-9-CM codesProtease inhibitor useFracture risk factorsMarkers of inflammationBody mass indexUpper arm fracturesAlcohol-related diagnosesCox regression modelFirst fragility fractureCause mortalityHIV RNAHemoglobin levelsMass index
2012
Receipt of Opioid Analgesics by HIV-Infected and Uninfected Patients
Edelman EJ, Gordon K, Becker WC, Goulet JL, Skanderson M, Gaither JR, Brennan Braden J, Gordon AJ, Kerns RD, Justice AC, Fiellin DA. Receipt of Opioid Analgesics by HIV-Infected and Uninfected Patients. Journal Of General Internal Medicine 2012, 28: 82-90. PMID: 22895747, PMCID: PMC3539026, DOI: 10.1007/s11606-012-2189-z.Peer-Reviewed Original ResearchConceptsLong-term opioidsHigh-dose opioidsUninfected patientsOpioid receiptHIV statusPain diagnosisHIV infectionVeterans Aging Cohort StudyVeterans Health Administration (VHA) careDaily morphine equivalent doseAcute pain diagnosisDays of opioidsMorphine equivalent doseAging Cohort StudyDesignCross-sectional analysisChronic pain diagnosesICD-9 codesVulnerable patient populationAverage daily doseMorphine equivalentsOpioid prescriptionsCohort studyDaily doseOpioid analgesicsPain management