2017
Discontinuing a non-steroidal anti-inflammatory drug (NSAID) in patients with knee osteoarthritis: Design and protocol of a placebo-controlled, noninferiority, randomized withdrawal trial
Goulet JL, Buta E, Brennan M, Heapy A, Fraenkel L. Discontinuing a non-steroidal anti-inflammatory drug (NSAID) in patients with knee osteoarthritis: Design and protocol of a placebo-controlled, noninferiority, randomized withdrawal trial. Contemporary Clinical Trials 2017, 65: 1-7. PMID: 29198731, DOI: 10.1016/j.cct.2017.11.020.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAdultAge FactorsAgedAged, 80 and overAnti-Inflammatory Agents, Non-SteroidalDisability EvaluationDouble-Blind MethodEquivalence Trials as TopicFemaleHumansMaleMeloxicamMiddle AgedOsteoarthritis, KneePain MeasurementPatient Education as TopicResearch DesignSeverity of Illness IndexSex FactorsSocial SupportYoung AdultConceptsNon-steroidal anti-inflammatory drugsUse of NSAIDsOA knee painKnee painKnee osteoarthritisAnti-inflammatory drugsWithdrawal trialCurrent non-steroidal anti-inflammatory drugsKnee OA painPainful knee osteoarthritisClasses of medicationsLower extremity disabilityTwo-week runFirst clinical trialVA healthcare systemOA painEligible subjectsSecondary outcomesPrimary outcomeGlobal ImpressionNSAID toxicityNoninferiority marginClinical trialsExtremity disabilityCommon causeInteractive Voice Response–Based Self-management for Chronic Back Pain: The COPES Noninferiority Randomized Trial
Heapy AA, Higgins DM, Goulet JL, LaChappelle KM, Driscoll MA, Czlapinski RA, Buta E, Piette JD, Krein SL, Kerns RD. Interactive Voice Response–Based Self-management for Chronic Back Pain: The COPES Noninferiority Randomized Trial. JAMA Internal Medicine 2017, 177: 765-773. PMID: 28384682, PMCID: PMC5818820, DOI: 10.1001/jamainternmed.2017.0223.Peer-Reviewed Original ResearchConceptsPerson cognitive-behavioural therapyChronic back painNumeric rating scaleCognitive behavioral therapyBack painChronic painPrimary outcomeSleep qualityVeterans Affairs Health Care SystemPrespecified noninferiority marginAverage pain intensityNonpharmacologic treatment optionsPain-related interferenceChronic pain treatmentSelf-management trialCognitive behavioral therapy deliveryIndividual CBT sessionsEvidence-based treatmentsQuality of lifeSelf-help manualHealth care systemIVR monitoringNonpharmacologic interventionsSecondary outcomesStandard therapy
2016
Cooperative pain education and self-management (COPES): study design and protocol of a randomized non-inferiority trial of an interactive voice response-based self-management intervention for chronic low back pain
Heapy AA, Higgins DM, LaChappelle KM, Kirlin J, Goulet JL, Czlapinski RA, Buta E, Piette JD, Krein SL, Richardson CR, Kerns RD. Cooperative pain education and self-management (COPES): study design and protocol of a randomized non-inferiority trial of an interactive voice response-based self-management intervention for chronic low back pain. BMC Musculoskeletal Disorders 2016, 17: 85. PMID: 26879051, PMCID: PMC4754867, DOI: 10.1186/s12891-016-0924-z.Peer-Reviewed Original ResearchConceptsChronic low back painLow back painNon-inferiority trialRandomized non-inferiority trialCognitive behavioral therapyPerson cognitive-behavioural therapyBack painClinical outcomesChronic pain conditionsNumeric rating scalePain-related interferencePatient-reported informationSelf-management interventionsEvidence-based treatmentsQuality of lifeUS military veteransStatewide health systemBackgroundThe InstituteIVR monitoringSecondary outcomesMore patientsPain conditionsPain intensityPrimary outcomeChronic pain