2017
The effect of substance use disorders on the association between guideline-concordant long-term opioid therapy and all-cause mortality
Gaither J, Goulet J, Becker W, Crystal S, Edelman E, Gordon K, Kerns R, Rimland D, Skanderson M, Justice A, Fiellin D. The effect of substance use disorders on the association between guideline-concordant long-term opioid therapy and all-cause mortality. Drug And Alcohol Dependence 2017, 171: e68. DOI: 10.1016/j.drugalcdep.2016.08.196.Peer-Reviewed Original Research
2016
The Effect of Substance Use Disorders on the Association Between Guideline-concordant Long-term Opioid Therapy and All-cause Mortality
Gaither JR, Goulet JL, Becker WC, Crystal S, Edelman EJ, Gordon K, Kerns RD, Rimland D, Skanderson M, Justice AC, Fiellin DA. The Effect of Substance Use Disorders on the Association Between Guideline-concordant Long-term Opioid Therapy and All-cause Mortality. Journal Of Addiction Medicine 2016, 10: 418-428. PMID: 27610580, PMCID: PMC5083184, DOI: 10.1097/adm.0000000000000255.Peer-Reviewed Original ResearchConceptsSubstance use disordersLong-term opioid therapyCause mortalityOpioid therapySUD treatmentUse disordersLower mortalityTime-updated Cox regressionUntreated substance use disordersVeterans Aging Cohort StudyOpioid-prescribing guidelinesGuideline-concordant careSUD statusAging Cohort StudyClinical practice guidelinesSUD treatment servicesOverall sampleHIV patientsCohort studyCox regressionPractice guidelinesPatientsTreatment servicesHigh mortalityMortalityDepression and HIV Infection Are Associated With Higher Risks of All-Cause Mortality in US Veterans: A Cohort Study
Gupta S, So-Armah K, Stewart J, Chang J, Goulet J, Freiberg M. Depression and HIV Infection Are Associated With Higher Risks of All-Cause Mortality in US Veterans: A Cohort Study. Open Forum Infectious Diseases 2016, 3: 2179. DOI: 10.1093/ofid/ofw172.1727.Peer-Reviewed Original ResearchA Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer.
Bradford DW, Goulet J, Hunt M, Cunningham NC, Hoff R. A Cohort Study of Mortality in Individuals With and Without Schizophrenia After Diagnosis of Lung Cancer. The Journal Of Clinical Psychiatry 2016, 77: e1626-e1630. PMID: 27780332, DOI: 10.4088/jcp.15m10281.Peer-Reviewed Original ResearchConceptsSerious mental illnessLung cancerMental illnessVeterans Affairs systemCause of deathSubstance use disordersLung cancer diagnosisCause mortalityCohort studyHazard ratioSmoking statusCommon malignancyCancer careLeading causePoor survivalHigh riskUse disordersSurvival analysisCancerMortalityIllnessSchizophreniaDiagnosisCancer diagnosisPotential disparities
2015
Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients
Weisberg DF, Gordon KS, Barry DT, Becker WC, Crystal S, Edelman EJ, Gaither J, Gordon AJ, Goulet J, Kerns RD, Moore BA, Tate J, Justice AC, Fiellin DA. Long-term Prescription of Opioids and/or Benzodiazepines and Mortality Among HIV-Infected and Uninfected Patients. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 69: 223-233. PMID: 26009831, PMCID: PMC4446730, DOI: 10.1097/qai.0000000000000591.Peer-Reviewed Original ResearchConceptsLong-term opioidsMorphine equivalent daily doseOpioid receiptRisk of deathLong-term prescriptionUninfected patientsOpioid dosesAntiretroviral therapyHazard ratioDaily dosePropensity scoreHigher opioid dosesCause mortalityHIV statusAvailable patientsMortality riskOpioidsHIVPatientsProspective analysisMortalityBenzodiazepinesDosesDeathRisk
2014
The VACS Index Accurately Predicts Mortality and Treatment Response among Multi-Drug Resistant HIV Infected Patients Participating in the Options in Management with Antiretrovirals (OPTIMA) Study
Brown ST, Tate JP, Kyriakides TC, Kirkwood KA, Holodniy M, Goulet JL, Angus BJ, Cameron DW, Justice AC, . The VACS Index Accurately Predicts Mortality and Treatment Response among Multi-Drug Resistant HIV Infected Patients Participating in the Options in Management with Antiretrovirals (OPTIMA) Study. PLOS ONE 2014, 9: e92606. PMID: 24667813, PMCID: PMC3965438, DOI: 10.1371/journal.pone.0092606.Peer-Reviewed Original ResearchConceptsVACS IndexCombination antiretroviral therapyNet reclassification improvementHIV biomarkersCause mortalityC-statisticTreatment interventionsMulti-drug resistant HIVHarrel's c-statisticsRespective hazard ratiosKaplan-Meier estimatesProportional hazards modelImproved scoresAntiretroviral studiesAntiretroviral therapyHazard ratioResistant HIVReclassification improvementRestricted IndexTreatment responseStudy interventionRisk scoreHazards modelVAC indexMortality
2009
Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans.
Crothers K, Goulet JL, Rodriguez-Barradas MC, Gibert CL, Oursler KA, Goetz MB, Crystal S, Leaf DA, Butt AA, Braithwaite RS, Peck R, Justice AC. Impact of cigarette smoking on mortality in HIV-positive and HIV-negative veterans. AIDS Education And Prevention 2009, 21: 40-53. PMID: 19537953, PMCID: PMC3118467, DOI: 10.1521/aeap.2009.21.3_supp.40.Peer-Reviewed Original ResearchConceptsHIV-negative veteransIncidence rate ratiosSmoking statusHIV-negative patientsSimilar mortality riskHIV-positive veteransComorbid diseasesCurrent smokingOverall mortalityCigarette smokingPoor outcomeMortality riskHIVPoisson regressionMortalitySmokingRate ratioVeteransDiseaseStudy of mechanismsLow levelsStatusSmokersPatientsCessation