IMST-56. TUMOR LYSATE-PULSED DC VACCINATION INDUCES NEOANTIGEN-SPECIFIC T CELL RESPONSES
Everson R, Shin N, Antonios J, Soto H, Tucker A, Zaretsky J, Orpilla J, Rathe S, Popescu F, Largaespada D, Liau L, Prins R. IMST-56. TUMOR LYSATE-PULSED DC VACCINATION INDUCES NEOANTIGEN-SPECIFIC T CELL RESPONSES. Neuro-Oncology 2016, 18: vi99-vi99. DOI: 10.1093/neuonc/now212.412.Peer-Reviewed Original ResearchAutologous tumor lysateTumor-infiltrating lymphocytesTumor-specific mutationsDC vaccinesDendritic cellsCD8+ T cell responsesEnhanced T cell infiltrationTumor-infiltrating lymphocyte culturesImmune responseIntracranial GL261 gliomasT cell infiltrationT cell responsesPhase III trialsTreatment groupsRelevant target antigensMurine glioma cell lineDC therapyTCR clonotypesTumor lysateGL261 gliomasIII trialsNeoantigen peptidesOriginal tumorGlioma cell linesLymphocytic infiltrationPD-1 blockade enhances the vaccination-induced immune response in glioma
Antonios J, Soto H, Everson R, Orpilla J, Moughon D, Shin N, Sedighim S, Yong W, Li G, Cloughesy T, Liau L, Prins R. PD-1 blockade enhances the vaccination-induced immune response in glioma. JCI Insight 2016, 1: e87059. PMID: 27453950, PMCID: PMC4951098, DOI: 10.1172/jci.insight.87059.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesPD-1 blockadeDC vaccinesPD-1/PD-L1PD-1Survival benefitMAb blockadeProgrammed death-1/programmed death-ligand 1Effect of PD-1 blockadeBlockade of PD-1Induced T cell infiltrationIsolated tumor-infiltrating lymphocytesPD-1 pathway inhibitionActive vaccinationCD8<sup>+</sup> T cellsPD-1/PD-L1 pathwayImmune responseVaccination-induced immune responsesAutologous tumor lysateIntratumoral immune responseNegative costimulatory pathwaysAdaptive immune resistanceDeath-ligand 1T cell infiltrationTumor cell cytolysis