1998
Activation and injury of endothelial cells by cytokines.
Pober JS. Activation and injury of endothelial cells by cytokines. Current Research In Translational Medicine 1998, 46: 159-63. PMID: 9769910.Peer-Reviewed Original ResearchConceptsJun N-terminal kinaseC-Jun/ATFNF-kappa BTRAF-2Activation of JNKNew gene expressionApoptosis of ECsProtein Rac-1Endothelial cellsAnti-apoptotic protein Bcl-2Transcription factor NF-kappa BN-terminal kinaseProtein synthesis inhibitor cycloheximideApoptotic proteins Bcl-2C-Jun synthesisFactor NF-kappa BPrimary cellular targetProtein Bcl-2CDC-42CrmA proteinKinase cascadeNF-kappa B activationHuman umbilical vein endothelial cellsAmino terminusUmbilical vein endothelial cells
1997
TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways.
Min W, Pober JS. TNF initiates E-selectin transcription in human endothelial cells through parallel TRAF-NF-kappa B and TRAF-RAC/CDC42-JNK-c-Jun/ATF2 pathways. The Journal Of Immunology 1997, 159: 3508-18. PMID: 9317150, DOI: 10.4049/jimmunol.159.7.3508.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2Antigens, SurfaceCalcium-Calmodulin-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinE-SelectinEndothelium, VascularGTP-Binding ProteinsHumansJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesNF-kappa BPhosphorylationPromoter Regions, GeneticProto-Oncogene Proteins c-junRac GTP-Binding ProteinsReceptors, Tumor Necrosis FactorTranscription FactorsTranscription, GeneticTumor Necrosis Factor Receptor-Associated Peptides and ProteinsTumor Necrosis Factor-alphaUmbilical VeinsConceptsTransient overexpressionHuman endothelial cellsC-JunSelectin transcriptionATF2/c-JunN-terminalATF2 pathwayPromoter-reporter geneKappa B elementCAMP-responsive elementEndothelial cellsDomain phosphorylationEndogenous JNKAdaptor proteinInactive JNKNF-kappa BGene transcriptionGene promoterKappa BJNK activationKinase 1TranscriptionTRAF2 proteinCdc42JNK
1996
Ceramide Is Not a Signal for Tumor Necrosis Factor–Induced Gene Expression but Does Cause Programmed Cell Death in Human Vascular Endothelial Cells
Slowik M, De Luca L, Min W, Pober J. Ceramide Is Not a Signal for Tumor Necrosis Factor–Induced Gene Expression but Does Cause Programmed Cell Death in Human Vascular Endothelial Cells. Circulation Research 1996, 79: 736-747. PMID: 8831497, DOI: 10.1161/01.res.79.4.736.Peer-Reviewed Original ResearchConceptsConcentrations of TNFNF-kappa BEndothelial cellsJun N-terminal kinaseNecrosis factorEndothelial leukocyte adhesion molecule-1Leukocyte adhesion molecule-1Treatment of ECCell deathCultured human umbilical vein endothelial cellsEndothelial leukocyte adhesion moleculeTumor necrosis factorAdhesion molecule-1Leukocyte adhesion moleculesHuman vascular endothelial cellsHuman umbilical vein endothelial cellsStimulation of ECUmbilical vein endothelial cellsVascular endothelial cellsP50/p65 heterodimeric formVein endothelial cellsPotential intracellular mediators