Mapping the chromatin and RNA expression landscapes of human macrophages to interrogate the function of disease-associated genetic polymorphisms
Martins A, Narayanan M, Fixsen B, Tsang J. Mapping the chromatin and RNA expression landscapes of human macrophages to interrogate the function of disease-associated genetic polymorphisms. The Journal Of Immunology 2017, 198: 59.15-59.15. DOI: 10.4049/jimmunol.198.supp.59.15.Peer-Reviewed Original ResearchSingle-nucleotide polymorphismsRegulatory elementsDisease-associated genetic polymorphismsGenome-wide association studiesGene expressionRegulatory element activityIdentified many single-nucleotide polymorphismsNon-coding regionsCondition-dependent activityHistone 3 lysineModulate gene expressionResponse to diverse stimuliMeasure gene expressionChromatin stateAssociation studiesTranscriptional networksGene modulesExpression landscapeFunctional enrichmentElement activityDiverse stimuliPromoter/enhancer activityGenetic polymorphismsDevelopment of diseaseChromatin