Featured Publications
Systematic Analysis of Cell-to-Cell Expression Variation of T Lymphocytes in a Human Cohort Identifies Aging and Genetic Associations
Lu Y, Biancotto A, Cheung F, Remmers E, Shah N, McCoy J, Tsang J. Systematic Analysis of Cell-to-Cell Expression Variation of T Lymphocytes in a Human Cohort Identifies Aging and Genetic Associations. Immunity 2016, 45: 1162-1175. PMID: 27851916, PMCID: PMC6532399, DOI: 10.1016/j.immuni.2016.10.025.Peer-Reviewed Original ResearchConceptsExpression variationDisease-associated genetic polymorphismsSingle-cell dataPrimary cell populationsCell populationsOrganismal levelFunctional associationDisease susceptibilityGenetic associationFlow cytometry dataCytometry dataGenetic polymorphismsHuman cohortsFlow cytometryCellsHigh-dimensional flow cytometryCell subpopulationsImportant rolePrevalent featureProteinPhenotypeSystematic analysisMultiple baseline measurementsPolymorphismPopulation
2017
Mapping the chromatin and RNA expression landscapes of human macrophages to interrogate the function of disease-associated genetic polymorphisms
Martins A, Narayanan M, Fixsen B, Tsang J. Mapping the chromatin and RNA expression landscapes of human macrophages to interrogate the function of disease-associated genetic polymorphisms. The Journal Of Immunology 2017, 198: 59.15-59.15. DOI: 10.4049/jimmunol.198.supp.59.15.Peer-Reviewed Original ResearchSingle-nucleotide polymorphismsRegulatory elementsDisease-associated genetic polymorphismsGenome-wide association studiesGene expressionRegulatory element activityIdentified many single-nucleotide polymorphismsNon-coding regionsCondition-dependent activityHistone 3 lysineModulate gene expressionResponse to diverse stimuliMeasure gene expressionChromatin stateAssociation studiesTranscriptional networksGene modulesExpression landscapeFunctional enrichmentElement activityDiverse stimuliPromoter/enhancer activityGenetic polymorphismsDevelopment of diseaseChromatin