Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach
Abdallah CG, Wrocklage KM, Averill CL, Akiki T, Schweinsburg B, Roy A, Martini B, Southwick SM, Krystal JH, Scott JC. Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach. Translational Psychiatry 2017, 7: e1045-e1045. PMID: 28244983, PMCID: PMC5545643, DOI: 10.1038/tp.2017.12.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityPosttraumatic stress disorderAnterior hippocampusStress disorderPTSD severityTraumatic brain injuryMultimodal approachOverall PTSD severityAnxiety-related behaviorDorsolateral prefrontal connectivityDorsolateral prefrontal cortexElevated PTSD symptomsAnatomical dysconnectivityHippocampal dysconnectivityUS veteransBrain injuryHippocampal volumePTSD subgroupBrain biomarkersClinical valueMedication statusPrefrontal connectivitySignificant associationPrefrontal cortexBrain connectivityThe Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities
Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG. The Association of PTSD Symptom Severity With Localized Hippocampus and Amygdala Abnormalities. Chronic Stress 2017, 1: 2470547017724069. PMID: 28825050, PMCID: PMC5562232, DOI: 10.1177/2470547017724069.Peer-Reviewed Original ResearchPosttraumatic stress disorderUS veteransAmygdala abnormalitiesVertex-wise shape analysisPTSD symptomsClinician-Administered PTSD ScaleCross-sectional studyHigh-resolution magnetic resonanceStructural neuroimaging studiesSevere PTSD symptomsHippocampal abnormalitiesPTSD symptom severitySubtle morphometric changesRe-experiencing symptomsRight hippocampusCentromedial amygdalaPTSD symptom clustersRight amygdalaPTSD ScaleAnterior hippocampusHippocampusStructural abnormalitiesDSM-IVSymptom clustersSymptom severity