1996
Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys
Elsworth J, Sladek J, Taylor J, Collier T, Redmond D, Roth R. Early gestational mesencephalon grafts, but not later gestational mesencephalon, cerebellum or sham grafts, increase dopamine in caudate nucleus of MPTP-treated monkeys. Neuroscience 1996, 72: 477-484. PMID: 8737417, DOI: 10.1016/0306-4522(95)00564-1.Peer-Reviewed Original ResearchConceptsFetal ventral mesencephalonVentral mesencephalonCaudate nucleusGraft siteDopamine neuronsDopamine concentrationsBehavioral recoveryTyrosine hydroxylase-positive neuronsHomovanillic acid/dopamine ratioFetal dopamine neuronsGrafted dopamine neuronsIntrastriatal transplantsParkinsonian primatesGrafted neuronsIntrastriatal transplantationGestational ageTransplant proceduresDopamine ratioDopamine productionSignificant elevationNucleus accumbensDopamine systemSham graftsGraftBrain regions
1990
3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation
Deutsch A, Elsworth J, Roth R, Menek G. 3-Acetylpyridine results in degeneration of the extrapyramidal and cerebellar motor systems: loss of the dorsolateral striatal dopamine innervation. Brain Research 1990, 527: 96-102. PMID: 2126479, DOI: 10.1016/0006-8993(90)91065-o.Peer-Reviewed Original ResearchConceptsCerebellar motor systemsDopamine innervationOlivocerebellar systemStriatal DA depletionStriatal dopamine innervationStriatal DA concentrationsMotor systemSelective inhibitor deprenylAnteromedial prefrontal cortexDeprenyl pretreatmentStriatal sectorsNigrostriatal degenerationDA innervationDA depletionDA levelsVentromedial striatumMAOB activitySensorimotor functionRats resultsNucleus accumbensDorsolateral aspectDorsolateral striatumMAOA activityDegenerationPrefrontal cortexChapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys
Taylor J, Elsworth J, Roth R, Collier T, Sladek J, Redmond D. Chapter 62 Improvements in MPTP-induced object retrieval deficits and behavioral deficits after fetal nigral grafting in monkeys. Progress In Brain Research 1990, 82: 543-559. PMID: 2290957, DOI: 10.1016/s0079-6123(08)62645-x.Peer-Reviewed Original ResearchConceptsCSF HVA levelsHVA levelsBehavioral recoveryCaudate nucleusSN graftsDopamine neuronsDopamine productionHVA/dopamine ratioCentral dopamine productionFetal substantia nigraStriatum of subjectsSubstantia nigra transplantsRelease of dopamineImproved parkinsonismHost striatumHost brainFetal graftsMPTP administrationParkinsonian signsTH immunohistochemistrySubstantia nigraDopamine ratioSmall graftsBehavioral deficitsGraft
1989
Transplantation advances in parkinson's disease
Sladek J, Redmond D, Collier T, Elsworth J, Roth R. Transplantation advances in parkinson's disease. Movement Disorders 1989, 4: s120-s125. PMID: 2786143, DOI: 10.1002/mds.870040513.Peer-Reviewed Original Research