1998
A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat
Taylor J, Punch L, Elsworth J. A comparison of the effects of clonidine and CNQX infusion into the locus coeruleus and the amygdala on naloxone-precipitated opiate withdrawal in the rat. Psychopharmacology 1998, 138: 133-142. PMID: 9718282, DOI: 10.1007/s002130050655.Peer-Reviewed Original Research
1991
Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats
Taylor J, Lewis V, Elsworth J, Pivirotto P, Roth R, Redmond D. Yohimbine co-treatment during chronic morphine administration attenuates naloxone-precipitated withdrawal without diminishing tail-flick analgesia in rats. Psychopharmacology 1991, 103: 407-414. PMID: 2057541, DOI: 10.1007/bf02244297.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsAnimalsBehavior, AnimalDrug ImplantsMaleMorphineNaloxoneRatsRats, Inbred StrainsReaction TimeSubstance Withdrawal SyndromeYohimbineConceptsChronic morphine administrationTail-flick latencyMorphine treatmentMorphine administrationMorphine withdrawalNoradrenergic activityAlpha 2 antagonist yohimbineAlpha-2 adrenergic receptorsTail-flick analgesiaChronic drug treatmentNaloxone-precipitated withdrawalDose-dependent mannerAdrenergic hyperactivityOpioid administrationOpioid analgesiaFlick latencyNeuronal hyperactivityMorphine pelletsWithdrawal signsAbnormal postureNoradrenergic systemPenile erectionSaline controlsDrug treatmentAnalgesia
1988
Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal
Taylor J, Elsworth J, Garcia E, Grant S, Roth R, Redmond D. Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal. Psychopharmacology 1988, 96: 121-134. PMID: 3147472, DOI: 10.1007/bf02431544.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBody WeightBrain ChemistryClonidineHippocampusInjectionsLocus CoeruleusMaleMethoxyhydroxyphenylglycolNaloxoneRatsRats, Inbred StrainsSubstance Withdrawal SyndromeConceptsNaloxone-precipitated withdrawalDorsal parabrachial nucleusAlpha-2 adrenergic receptorsWet dog shakesLocus coeruleusClonidine infusionMHPG concentrationsOpiate withdrawalAlpha-2 adrenergic agonistsAnti-withdrawal actionWithdrawal-induced increasesBlood-brain barrierInfusion of clonidineNucleus locus coeruleusOccurrence of diarrheaClonidine's abilityLC infusionBrain concentrationsNoradrenergic neuronsST-91MHPG levelsPeripheral injectionWithdrawal signsNeurochemical changesParabrachial nucleus
1986
Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain
Elsworth J, Redmond D, Roth R. Effect of morphine treatment and withdrawal on endogenous methionine- and leucine-enkephalin levels in primate brain. Biochemical Pharmacology 1986, 35: 3415-3417. PMID: 3768031, DOI: 10.1016/0006-2952(86)90447-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain ChemistryChlorocebus aethiopsEnkephalin, LeucineEnkephalin, MethionineFemaleMaleMorphineNaltrexoneSubstance Withdrawal Syndrome
1982
Brain catecholamine metabolites and behavior in morphine withdrawal
Swann A, Elsworth J, Charney D, Jablons D, Roth R, Redmond D, Maas J. Brain catecholamine metabolites and behavior in morphine withdrawal. European Journal Of Pharmacology 1982, 86: 167-175. PMID: 6297931, DOI: 10.1016/0014-2999(82)90314-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBrain ChemistryCatecholaminesDebrisoquinHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMorphine DependenceRatsReceptors, OpioidSubstance Withdrawal SyndromeSynaptosomesConceptsCatecholamine metabolitesMorphine withdrawal behaviorsBeta-receptor bindingWithdrawal behaviorDebrisoquin sulfateAcute treatmentMorphine withdrawalNorepinephrine metaboliteMorphine pelletsWithdrawal signsPlasma levelsBrain 3Noradrenergic hyperactivityReceptor bindingMHPGBrainMetabolitesNaloxoneHVARatsHyperactivityClonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.
Roth R, Elsworth J, Redmond D. Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates. The Journal Of Clinical Psychiatry 1982, 43: 42-6. PMID: 6806253.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainClonidineDose-Response Relationship, DrugHaplorhiniHumansMethoxyhydroxyphenylglycolMorphine DependenceNaloxoneNeuronsNorepinephrineRatsSubstance Withdrawal SyndromeConceptsBrain levelsMHPG accumulationNE turnoverNE neuronsLocus coeruleusNaloxone-insensitive mechanismAdministration of naloxoneMorphine-dependent animalsNE systemDose-dependent degreeNon-human primatesNE metabolismMorphine withdrawalOpiate withdrawalClonidine suppressionImpulse flowNoradrenergic hyperactivityClinical studiesCSF measuresControl monkeysClonidineElectrophysiological studiesMHPGBiochemical measuresPilot data