1996
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure
Horger B, Taylor J, Elsworth J, Jatlow P, Roth R. Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Research 1996, 733: 133-137. PMID: 8891259, DOI: 10.1016/0006-8993(96)00783-4.Peer-Reviewed Original Research
1994
Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization
Horger B, Taylor J, Elsworth J, Roth R. Preexposure to, but Not Cotreatment with, the Neurotensin Antagonist SR 48692 Delays the Development of Cocaine Sensitization. Neuropsychopharmacology 1994, 11: 215-222. PMID: 7865101, DOI: 10.1038/sj.npp.1380108.Peer-Reviewed Original ResearchConceptsCocaine challenge injectionSR 48692Role of neurotensinDevelopment of sensitizationEffects of cocaineCocaine sensitizationChallenge injectionDay drug-free periodMale Sprague-Dawley ratsCocaine-induced locomotor activityDrug-free periodSprague-Dawley ratsCocaine-induced locomotor activationCocaine-induced activityDrug-free daysEffects of cotreatmentPreexposure injectionsDaily administrationLocomotor activationCocaine testLocomotor deficitsLocomotor activityActivity countsChronic preexposureCocaine testing
1993
Serotonin involvement in cocaine sensitization: Clues from studies with cocaine analogs
Elsworth J, Taylor J, Jatlow P, Roth R. Serotonin involvement in cocaine sensitization: Clues from studies with cocaine analogs. Drug Development Research 1993, 30: 189-200. DOI: 10.1002/ddr.430300311.Peer-Reviewed Original ResearchLocomotor activityAcute dose-response studySubsequent challenge doseΒ-CITCentral dopamine systemsInhibitor of serotoninDopamine uptake sitesCocaine-induced sensitizationInhibitors of dopamineDose-response studyUptake of dopamineRat locomotor activitySerotonin componentConcurrent ingestionChallenge doseSerotonin uptakeNorepinephrine uptakeSerotonergic systemChronic cocaineDopamine systemDopamine uptakeCocaine actionUptake sitesBehavioral effectsComparative potency