2001
Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine
Zachariou V, Caldarone B, Weathers-Lowin A, George T, Elsworth J, Roth R, Changeux J, Picciotto M. Nicotine Receptor Inactivation Decreases Sensitivity to Cocaine. Neuropsychopharmacology 2001, 24: 576-589. PMID: 11282258, DOI: 10.1016/s0893-133x(00)00224-4.Peer-Reviewed Original ResearchConceptsPlace preferenceDA turnoverLow doseHigh-affinity nicotinic acetylcholine receptorsMesolimbic DA systemHigh-affinity nAChRsNicotinic antagonist mecamylamineWild-type miceMesolimbic dopamine systemFos-related antigensProperties of nicotineCocaine place preferenceΒ2 subunitNicotinic acetylcholine receptorsAntagonist mecamylamineDA releaseMetabolite DOPACNeurochemical changesSubthreshold doseType miceDopamine systemPsychomotor stimulantsAcetylcholine receptorsHigh dosesBrain regions
1997
Phencyclidine Increases Forebrain Monoamine Metabolism in Rats and Monkeys: Modulation by the Isomers of HA966
Jentsch J, Elsworth J, Redmond D, Roth R. Phencyclidine Increases Forebrain Monoamine Metabolism in Rats and Monkeys: Modulation by the Isomers of HA966. Journal Of Neuroscience 1997, 17: 1769-1775. PMID: 9030635, PMCID: PMC6573388, DOI: 10.1523/jneurosci.17-05-01769.1997.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsChlorocebus aethiopsDopamineExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsFrontal LobeIsomerismMaleNeuronsPhencyclidineProsencephalonPyrrolidinonesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateSchizophrenic PsychologySerotoninSpecies SpecificitySubstantia NigraTegmentum MesencephaliConceptsPCP-induced increasePrefrontal cortexDA turnoverMonoamine metabolismFrontal cortexNucleus accumbensNMDA receptor antagonist phencyclidinePCP-induced changesForebrain of ratsMonkey frontal cortexEffects of PCPDrug-induced activationMedial prefrontal cortexMonoamine transmissionSerotonergic innervationDopamine innervationSerotonin turnoverDopamine turnoverSerotonin utilizationPsychotomimetic propertiesDopamine transmissionDopamine systemBrain regionsPotent effectsRats